Canonical correlation analysis for multi-omics: Application to cross-cohort analysis

• Min-Zhi Jiang,

  Roles Data curation, Formal analysis, Investigation, Methodology, Software, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Applied Physical Sciences, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

  https://orcid.org/0000-0001-5502-063X

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• François Aguet,

  Roles Writing – review & editing

  Affiliation Illumina Artificial Intelligence Laboratory, Illumina, Inc., San Diego, California, United States of America

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• Kristin Ardlie,

  Roles Writing – review & editing

  Affiliation The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

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• Jiawen Chen,

  Roles Visualization, Writing – review & editing

  Affiliation Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

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• Elaine Cornell,

  Roles Writing – review & editing

  Affiliation Laboratory for Clinical Biochemistry Research, University of Vermont, Burlington, Vermont, United States of America

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• Dan Cruz,

  Roles Writing – review & editing

  Affiliation Department of Medicine, Cardiology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America

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• Peter Durda,

  Roles Writing – review & editing

  Affiliation Department of Pathology & Laboratory Medicine, University of Vermont, Colchester, Vermont, United States of America

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• Stacey B. Gabriel,

  Roles Writing – review & editing

  Affiliation The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

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• Robert E. Gerszten,

  Roles Writing – review & editing

  Affiliation Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America

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• Xiuqing Guo,

  Roles Writing – review & editing

  Affiliation Department of Pediatrics, The Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, University of California at Los Angeles, Torrance, California, United States of America

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• Craig W. Johnson,

  Roles Writing – review & editing

  Affiliation Department of Biostatistics, University of Washington at Seattle, Seattle, Washington, United States of America

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• Silva Kasela,

  Roles Writing – review & editing

  Affiliation New York Genome Center, New York, New York, United States of America

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• Leslie A. Lange,

  Roles Writing – review & editing

  Affiliation Department of Epidemiology, Department of Medicine, Division of Biomedical Informatics and Personalized Medicine, Lifecourse Epidemiology of Adiposity & Diabetes Center, Aurora, Colorado, United States of America

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• Tuuli Lappalainen,

  Roles Writing – review & editing

  Affiliation New York Genome Center, New York, New York, United States of America

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• Yongmei Liu,

  Roles Writing – review & editing

  Affiliation Department of Medicine, Cardiology and Neurology, Duke University Medical Center, Durham, North Carolina, United States of America

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• Alex P. Reiner,

  Roles Writing – review & editing

  Affiliation Department of Epidemiology, University of Washington, Seattle, Washington, United States of America

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• Josh Smith,

  Roles Writing – review & editing

  Affiliation Northwest Genomic Center, University of Washington, Seattle, Washington, United States of America

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• Tamar Sofer,

  Roles Writing – review & editing

  Affiliation Department of Biostatistics, Harvard Medical School, Medicine-Brigham and Women’s Hospital, Boston, Massachusetts, United States of America

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• Kent D. Taylor,

  Roles Writing – review & editing

  Affiliation Department of Pediatrics, The Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, University of California at Los Angeles, Torrance, California, United States of America

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• Russell P. Tracy,

  Roles Writing – review & editing

  Affiliation Department of Pathology & Laboratory Medicine, University of Vermont, Colchester, Vermont, United States of America

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• David J. VanDenBerg,

  Roles Writing – review & editing

  Affiliation Department of Preventive Medicine, University of Southern California, Los Angeles, California, United States of America

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• James G. Wilson,

  Roles Resources, Writing – review & editing

  Affiliation Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America

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• Stephen S. Rich,

  Roles Resources, Writing – review & editing

  Affiliation Center for Public Health Genomics, Department of Public Health Sciences, University of Virginia, Charlottesville, Virginia, United States of America

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• Jerome I. Rotter,

  Roles Resources, Writing – review & editing

  Affiliation Department of Pediatrics, Genomic Outcomes, The Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, University of California at Los Angeles, Torrance, California, United States of America

  https://orcid.org/0000-0001-7191-1723

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• Michael I. Love ,

  Contributed equally to this work with: Michael I. Love, Laura M. Raffield, Yun Li

  Roles Conceptualization, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: milove@email.unc.edu (MIL); laura_raffield@unc.edu (LMR); yunli@med.unc.edu (YL)

  Affiliations Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America, Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

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• Laura M. Raffield ,

  Contributed equally to this work with: Michael I. Love, Laura M. Raffield, Yun Li

  Roles Conceptualization, Data curation, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: milove@email.unc.edu (MIL); laura_raffield@unc.edu (LMR); yunli@med.unc.edu (YL)

  Affiliation Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

  https://orcid.org/0000-0002-7892-193X

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• Yun Li ,

  Contributed equally to this work with: Michael I. Love, Laura M. Raffield, Yun Li

  Roles Conceptualization, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: milove@email.unc.edu (MIL); laura_raffield@unc.edu (LMR); yunli@med.unc.edu (YL)

  Affiliations Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America, Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

  https://orcid.org/0000-0002-9275-4189

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•  [ ... ],
• NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, TOPMed Analysis Working Group

  ¶Members are listed in S1 Acknowledgement.

  ¶Members are listed in S1 Acknowledgement.

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