Understanding a high-risk acute myeloid leukemia by analyzing the interactome of its major driver mutation

Claudia Chiriches; Nathalie Nicolaisen; Maria Wieske; Heba Elhaddad; Ecmel Mehmetbeyoglu; Caroline Alvares; Dörte Becher; Paul Hole; Oliver Gerhard Ottmann; Martin Ruthardt

doi:10.1371/journal.pgen.1010463

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Peer-reviewed

Research Article

Understanding a high-risk acute myeloid leukemia by analyzing the interactome of its major driver mutation

Claudia Chiriches ,

Contributed equally to this work with: Claudia Chiriches, Nathalie Nicolaisen, Maria Wieske

Roles Conceptualization, Data curation, Formal analysis, Investigation, Project administration, Software, Supervision, Writing – original draft, Writing – review & editing

* E-mail: chirichesc@cardiff.ac.uk (CC); ruthardtm@cardiff.ac.uk (MR)

Affiliations Division of Cancer and Genetics, Section of Hematology, School of Medicine, Cardiff University, Cardiff, United Kingdom, Experimental Clinical Medical Center (ECMC) Cardiff, School of Medicine, Cardiff University, Cardiff, United Kingdom

https://orcid.org/0000-0003-3758-1892

⨯
Nathalie Nicolaisen ,

Contributed equally to this work with: Claudia Chiriches, Nathalie Nicolaisen, Maria Wieske

Roles Funding acquisition, Investigation, Methodology

Affiliation Department of Hematology, Medical Clinic II Goethe University Frankfurt, Germany

https://orcid.org/0000-0002-8366-3787

⨯
Maria Wieske ,

Contributed equally to this work with: Claudia Chiriches, Nathalie Nicolaisen, Maria Wieske

Roles Data curation, Formal analysis, Investigation, Methodology, Software

Affiliation Department of Hematology, Medical Clinic II Goethe University Frankfurt, Germany

https://orcid.org/0000-0003-4485-8802

⨯
Heba Elhaddad,

Roles Formal analysis, Funding acquisition, Investigation, Validation

Affiliations Division of Cancer and Genetics, Section of Hematology, School of Medicine, Cardiff University, Cardiff, United Kingdom, Experimental Clinical Medical Center (ECMC) Cardiff, School of Medicine, Cardiff University, Cardiff, United Kingdom, Faculty of Medicine, Department of Clinical Pathology, Mansoura University, Mansoura, Egypt

https://orcid.org/0000-0002-6968-9884

⨯
Ecmel Mehmetbeyoglu,

Roles Funding acquisition, Investigation, Methodology, Validation

Affiliations Division of Cancer and Genetics, Section of Hematology, School of Medicine, Cardiff University, Cardiff, United Kingdom, Experimental Clinical Medical Center (ECMC) Cardiff, School of Medicine, Cardiff University, Cardiff, United Kingdom

https://orcid.org/0000-0002-4597-6811

⨯
Caroline Alvares,

Roles Supervision, Writing – review & editing

Affiliations Division of Cancer and Genetics, Section of Hematology, School of Medicine, Cardiff University, Cardiff, United Kingdom, Experimental Clinical Medical Center (ECMC) Cardiff, School of Medicine, Cardiff University, Cardiff, United Kingdom

https://orcid.org/0000-0003-4391-9802

⨯
Dörte Becher,

Roles Methodology, Supervision

Affiliation Institute of Microbiology, Microbial Proteomics, Ernst Moritz Arndt University, Greifswald, Germany

https://orcid.org/0000-0002-9630-5735

⨯
Paul Hole,

Roles Funding acquisition, Methodology, Writing – review & editing

Affiliations Division of Cancer and Genetics, Section of Hematology, School of Medicine, Cardiff University, Cardiff, United Kingdom, Experimental Clinical Medical Center (ECMC) Cardiff, School of Medicine, Cardiff University, Cardiff, United Kingdom

https://orcid.org/0000-0001-7660-997X

⨯
Oliver Gerhard Ottmann,

Roles Funding acquisition, Writing – original draft, Writing – review & editing

Affiliations Division of Cancer and Genetics, Section of Hematology, School of Medicine, Cardiff University, Cardiff, United Kingdom, Experimental Clinical Medical Center (ECMC) Cardiff, School of Medicine, Cardiff University, Cardiff, United Kingdom

https://orcid.org/0000-0001-9559-1330

⨯
Martin Ruthardt

Roles Conceptualization, Data curation, Funding acquisition, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

* E-mail: chirichesc@cardiff.ac.uk (CC); ruthardtm@cardiff.ac.uk (MR)

Affiliations Division of Cancer and Genetics, Section of Hematology, School of Medicine, Cardiff University, Cardiff, United Kingdom, Experimental Clinical Medical Center (ECMC) Cardiff, School of Medicine, Cardiff University, Cardiff, United Kingdom

https://orcid.org/0000-0003-1021-3811

⨯

Understanding a high-risk acute myeloid leukemia by analyzing the interactome of its major driver mutation

Claudia Chiriches,
Nathalie Nicolaisen,
Maria Wieske,
Heba Elhaddad,
Ecmel Mehmetbeyoglu,
Caroline Alvares,
Dörte Becher,
Paul Hole,
Oliver Gerhard Ottmann,
Martin Ruthardt

Published: October 26, 2022
https://doi.org/10.1371/journal.pgen.1010463

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