TGFβ pathway is required for viable gestation of Fanconi anemia embryos

Alfredo Rodríguez; Michael Epperly; Jessica Filiatrault; Martha Velázquez; Chunyu Yang; Kelsey McQueen; Larissa A. Sambel; Huy Nguyen; Divya Ramalingam Iyer; Ulises Juárez; Cecilia Ayala-Zambrano; David B. Martignetti; Sara Frías; Renee Fisher; Kalindi Parmar; Joel S. Greenberger; Alan D. D’Andrea

doi:10.1371/journal.pgen.1010459

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Peer-reviewed

Research Article

TGFβ pathway is required for viable gestation of Fanconi anemia embryos

Alfredo Rodríguez,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – original draft, Writing – review & editing

Affiliations Department of Radiation Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, United States of America, Departamento de Medicina Genómica y Toxicología Ambiental, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Ciudad Universitaria, México, México, Instituto Nacional de Pediatría, Mexico City, Mexico

https://orcid.org/0000-0002-1072-8631

⨯
Michael Epperly,

Roles Conceptualization, Formal analysis, Investigation, Methodology

Affiliation University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States of America
⨯
Jessica Filiatrault,

Roles Investigation

Affiliation Department of Radiation Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, United States of America
⨯
Martha Velázquez,

Roles Formal analysis, Investigation, Methodology

Affiliation Department of Radiation Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, United States of America
⨯
Chunyu Yang,

Roles Investigation, Methodology

Affiliations Department of Radiation Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, United States of America, Center for DNA Damage and DNA Repair, Dana Farber Cancer Institute, Boston, Massachusetts, United States of America
⨯
Kelsey McQueen,

Roles Investigation, Methodology

Affiliations Department of Radiation Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, United States of America, Center for DNA Damage and DNA Repair, Dana Farber Cancer Institute, Boston, Massachusetts, United States of America
⨯
Larissa A. Sambel,

Roles Methodology

Affiliations Department of Radiation Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, United States of America, Center for DNA Damage and DNA Repair, Dana Farber Cancer Institute, Boston, Massachusetts, United States of America
⨯
Huy Nguyen,

Roles Data curation, Formal analysis, Methodology, Software, Visualization

Affiliations Department of Radiation Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, United States of America, Center for DNA Damage and DNA Repair, Dana Farber Cancer Institute, Boston, Massachusetts, United States of America
⨯
Divya Ramalingam Iyer,

Roles Formal analysis, Investigation, Methodology

Affiliation Department of Radiation Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, United States of America

https://orcid.org/0000-0002-2306-052X

⨯
Ulises Juárez,

Roles Data curation, Formal analysis, Methodology

Affiliation Instituto Nacional de Pediatría, Mexico City, Mexico
⨯
Cecilia Ayala-Zambrano,

Roles Investigation, Methodology

Affiliations Department of Radiation Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, United States of America, Instituto Nacional de Pediatría, Mexico City, Mexico, Posgrado en Ciencias Biológicas, UNAM, Ciudad Universitaria, México, México
⨯
David B. Martignetti,

Roles Investigation, Methodology

Affiliation Department of Radiation Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, United States of America
⨯
Sara Frías,

Roles Funding acquisition, Supervision

Affiliations Departamento de Medicina Genómica y Toxicología Ambiental, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Ciudad Universitaria, México, México, Instituto Nacional de Pediatría, Mexico City, Mexico

https://orcid.org/0000-0002-3097-6368

⨯
Renee Fisher,

Roles Conceptualization, Formal analysis, Investigation, Methodology, Project administration, Supervision

Affiliation University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States of America
⨯
Kalindi Parmar,

Roles Conceptualization, Formal analysis, Investigation, Methodology, Project administration, Writing – review & editing

Affiliations Department of Radiation Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, United States of America, Center for DNA Damage and DNA Repair, Dana Farber Cancer Institute, Boston, Massachusetts, United States of America
⨯
Joel S. Greenberger,

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Writing – original draft

Affiliation University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States of America
⨯
[ ... ],
Alan D. D’Andrea

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

* E-mail: Alan_Dandrea@dfci.harvard.edu

Affiliations Department of Radiation Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, United States of America, Center for DNA Damage and DNA Repair, Dana Farber Cancer Institute, Boston, Massachusetts, United States of America
⨯
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TGFβ pathway is required for viable gestation of Fanconi anemia embryos

Alfredo Rodríguez,
Michael Epperly,
Jessica Filiatrault,
Martha Velázquez,
Chunyu Yang,
Kelsey McQueen,
Larissa A. Sambel,
Huy Nguyen,
Divya Ramalingam Iyer,
Ulises Juárez

Published: November 28, 2022
https://doi.org/10.1371/journal.pgen.1010459

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