The entry of unclosed autophagosomes into vacuoles and its physiological relevance

Zulin Wu; Haiqian Xu; Pei Wang; Ling Liu; Juan Cai; Yun Chen; Xiaomin Zhao; Xia You; Junze Liu; Xiangrui Guo; Tingting Xie; Jiajie Feng; Fan Zhou; Rui Li; Zhiping Xie; Yanhong Xue; Chuanhai Fu; Yongheng Liang

doi:10.1371/journal.pgen.1010431

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Open Access

Peer-reviewed

Research Article

The entry of unclosed autophagosomes into vacuoles and its physiological relevance

Zulin Wu ,

Contributed equally to this work with: Zulin Wu, Haiqian Xu, Pei Wang, Ling Liu, Juan Cai, Yun Chen

Roles Formal analysis, Investigation, Methodology, Validation, Visualization

Affiliation College of Life Sciences, Key Laboratory of Agricultural Environmental Microbiology of Ministry of Agriculture and Rural Affairs, Nanjing Agricultural University, Nanjing, China
⨯
Haiqian Xu ,

Contributed equally to this work with: Zulin Wu, Haiqian Xu, Pei Wang, Ling Liu, Juan Cai, Yun Chen

Roles Formal analysis, Investigation, Validation, Visualization

Affiliation College of Life Sciences, Key Laboratory of Agricultural Environmental Microbiology of Ministry of Agriculture and Rural Affairs, Nanjing Agricultural University, Nanjing, China
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Pei Wang ,

Contributed equally to this work with: Zulin Wu, Haiqian Xu, Pei Wang, Ling Liu, Juan Cai, Yun Chen

Roles Formal analysis, Investigation, Methodology, Validation, Visualization

Affiliations National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China, University of Chinese Academy of Sciences, Beijing, China
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Ling Liu ,

Contributed equally to this work with: Zulin Wu, Haiqian Xu, Pei Wang, Ling Liu, Juan Cai, Yun Chen

Roles Formal analysis, Investigation, Methodology, Validation, Visualization

Affiliation Ministry of Education Key Laboratory for Membrane-less Organelles & Cellular Dynamics, CAS Center for Excellence in Molecular Cell Sciences, Hefei National Laboratory for Physical Sciences at the Microscale, School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China
⨯
Juan Cai ,

Contributed equally to this work with: Zulin Wu, Haiqian Xu, Pei Wang, Ling Liu, Juan Cai, Yun Chen

Roles Formal analysis, Investigation, Validation, Visualization

Affiliation College of Life Sciences, Key Laboratory of Agricultural Environmental Microbiology of Ministry of Agriculture and Rural Affairs, Nanjing Agricultural University, Nanjing, China
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Yun Chen ,

Contributed equally to this work with: Zulin Wu, Haiqian Xu, Pei Wang, Ling Liu, Juan Cai, Yun Chen

Roles Formal analysis, Investigation, Validation, Visualization

Affiliation College of Life Sciences, Key Laboratory of Agricultural Environmental Microbiology of Ministry of Agriculture and Rural Affairs, Nanjing Agricultural University, Nanjing, China
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Xiaomin Zhao,

Roles Investigation, Methodology, Visualization

Affiliation College of Life Sciences, Key Laboratory of Agricultural Environmental Microbiology of Ministry of Agriculture and Rural Affairs, Nanjing Agricultural University, Nanjing, China
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Xia You,

Roles Investigation, Visualization

Affiliation College of Life Sciences, Key Laboratory of Agricultural Environmental Microbiology of Ministry of Agriculture and Rural Affairs, Nanjing Agricultural University, Nanjing, China
⨯
Junze Liu,

Roles Investigation, Visualization

Affiliation College of Life Sciences, Key Laboratory of Agricultural Environmental Microbiology of Ministry of Agriculture and Rural Affairs, Nanjing Agricultural University, Nanjing, China
⨯
Xiangrui Guo,

Roles Investigation, Validation

Affiliation College of Life Sciences, Key Laboratory of Agricultural Environmental Microbiology of Ministry of Agriculture and Rural Affairs, Nanjing Agricultural University, Nanjing, China
⨯
Tingting Xie,

Roles Investigation, Visualization

Affiliation College of Life Sciences, Key Laboratory of Agricultural Environmental Microbiology of Ministry of Agriculture and Rural Affairs, Nanjing Agricultural University, Nanjing, China
⨯
Jiajie Feng,

Roles Investigation, Methodology, Visualization

Affiliation College of Life Sciences, Key Laboratory of Agricultural Environmental Microbiology of Ministry of Agriculture and Rural Affairs, Nanjing Agricultural University, Nanjing, China
⨯
Fan Zhou,

Roles Investigation, Methodology

Affiliation College of Life Sciences, Key Laboratory of Agricultural Environmental Microbiology of Ministry of Agriculture and Rural Affairs, Nanjing Agricultural University, Nanjing, China
⨯
Rui Li,

Roles Investigation

Affiliation College of Life Sciences, Key Laboratory of Agricultural Environmental Microbiology of Ministry of Agriculture and Rural Affairs, Nanjing Agricultural University, Nanjing, China
⨯
Zhiping Xie,

Roles Funding acquisition, Resources

Affiliation State Key Laboratory of Microbial Metabolism, School of Life Sciences and Technology, Shanghai Jiao Tong University, Shanghai, China
⨯
Yanhong Xue ,

Roles Data curation, Formal analysis, Funding acquisition, Project administration, Resources, Supervision, Validation, Writing – original draft, Writing – review & editing

* E-mail: xueyanhong@ibp.ac.cn (YX); chuanhai@ustc.edu.cn (CF); liangyh@njau.edu.cn (YL)

Affiliation National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China
⨯
Chuanhai Fu ,

Roles Data curation, Formal analysis, Project administration, Resources, Supervision, Validation, Writing – review & editing

* E-mail: xueyanhong@ibp.ac.cn (YX); chuanhai@ustc.edu.cn (CF); liangyh@njau.edu.cn (YL)

Affiliation Ministry of Education Key Laboratory for Membrane-less Organelles & Cellular Dynamics, CAS Center for Excellence in Molecular Cell Sciences, Hefei National Laboratory for Physical Sciences at the Microscale, School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China
⨯
[ ... ],
Yongheng Liang

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Project administration, Resources, Supervision, Validation, Writing – original draft, Writing – review & editing

* E-mail: xueyanhong@ibp.ac.cn (YX); chuanhai@ustc.edu.cn (CF); liangyh@njau.edu.cn (YL)

Affiliation College of Life Sciences, Key Laboratory of Agricultural Environmental Microbiology of Ministry of Agriculture and Rural Affairs, Nanjing Agricultural University, Nanjing, China

https://orcid.org/0000-0002-5430-2042

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The entry of unclosed autophagosomes into vacuoles and its physiological relevance

Zulin Wu,
Haiqian Xu,
Pei Wang,
Ling Liu,
Juan Cai,
Yun Chen,
Xiaomin Zhao,
Xia You,
Junze Liu,
Xiangrui Guo

Published: October 13, 2022
https://doi.org/10.1371/journal.pgen.1010431

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Vacuoles
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Antigen-presenting cells
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Autophagic cell death
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Yeast
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Proteases
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Plant vacuoles
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Immunoblotting
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