A Drosophila Su(H) model of Adams-Oliver Syndrome reveals cofactor titration as a mechanism underlying developmental defects

• Ellen K. Gagliani ,

  Contributed equally to this work with: Ellen K. Gagliani, Lisa M. Gutzwiller

  Roles Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America

  https://orcid.org/0000-0001-7270-6254

  ⨯
• Lisa M. Gutzwiller ,

  Contributed equally to this work with: Ellen K. Gagliani, Lisa M. Gutzwiller

  Roles Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Division of Developmental Biology, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, United States of America

  https://orcid.org/0000-0001-8583-8328

  ⨯
• Yi Kuang,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliation Graduate program in Molecular and Developmental Biology, Cincinnati Children’s Hospital Research Foundation, Cincinnati, Ohio, United States of America

  https://orcid.org/0000-0002-1509-3620

  ⨯
• Yoshinobu Odaka,

  Roles Formal analysis, Investigation, Methodology, Writing – original draft

  Affiliation Biology Department, University of Cincinnati Blue Ash College, Cincinnati, Ohio, United States of America

  https://orcid.org/0000-0003-3966-5475

  ⨯
• Phillipp Hoffmeister,

  Roles Formal analysis, Investigation, Methodology

  Affiliation University Medical Center Ulm, Center for Internal Medicine, Department of Internal Medicine, Ulm, Germany

  https://orcid.org/0000-0001-6065-4290

  ⨯
• Stefanie Hauff,

  Roles Formal analysis, Investigation, Methodology

  Affiliation University Medical Center Ulm, Center for Internal Medicine, Department of Internal Medicine, Ulm, Germany

  ⨯
• Aleksandra Turkiewicz,

  Roles Formal analysis, Investigation, Methodology

  Affiliation Institute of Biochemistry, University of Giessen, Giessen, Germany

  https://orcid.org/0000-0002-4386-1180

  ⨯
• Emily Harding-Theobald,

  Roles Formal analysis, Investigation, Methodology

  Affiliation Department of Biology, Dartmouth College, Hanover, New Hampshire, United States of America

  https://orcid.org/0000-0003-0810-8596

  ⨯
• Patrick J. Dolph,

  Roles Formal analysis, Investigation, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  Affiliation Department of Biology, Dartmouth College, Hanover, New Hampshire, United States of America

  https://orcid.org/0000-0001-9770-727X

  ⨯
• Tilman Borggrefe,

  Roles Formal analysis, Funding acquisition, Investigation, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  Affiliation Institute of Biochemistry, University of Giessen, Giessen, Germany

  ⨯
• Franz Oswald,

  Roles Formal analysis, Funding acquisition, Investigation, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  Affiliation University Medical Center Ulm, Center for Internal Medicine, Department of Internal Medicine, Ulm, Germany

  https://orcid.org/0000-0002-2923-5765

  ⨯
• Brian Gebelein ,

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: Brian.Gebelein@cchmc.org (BG); kovallra@ucmail.uc.edu (RAK)

  Affiliations Division of Developmental Biology, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, United States of America, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America

  https://orcid.org/0000-0001-9791-9061

  ⨯
• Rhett A. Kovall

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: Brian.Gebelein@cchmc.org (BG); kovallra@ucmail.uc.edu (RAK)

  Affiliation Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America

  https://orcid.org/0000-0003-0520-1613

  ⨯