Constraints on the evolution of toxin-resistant Na,K-ATPases have limited dependence on sequence divergence

• Shabnam Mohammadi ,

  Roles Data curation, Formal analysis, Funding acquisition, Investigation, Visualization, Writing – original draft, Writing – review & editing

  ¶‡ These authors share first authorship on this work.

  Affiliations School of Biological Sciences, University of Nebraska, Lincoln, Nebraska, United States of America, Molecular Evolutionary Biology, Institut für Zell- und Systembiologie der Tiere, Universität Hamburg, Hamburg, Germany

  https://orcid.org/0000-0003-3450-6424

  ⨯
• Santiago Herrera-Álvarez ,

  Roles Data curation, Formal analysis, Investigation, Visualization, Writing – review & editing

  ¶‡ These authors share first authorship on this work.

  Affiliations Department of Biological Sciences, Universidad de los Andes, Bogotá, Colombia, Department of Ecology and Evolution, University of Chicago, Chicago, Illinois, United States of America

  https://orcid.org/0000-0002-0793-7811

  ⨯
• Lu Yang,

  Roles Data curation, Formal analysis, Investigation, Writing – review & editing

  Affiliation Department of Ecology and Evolution, Princeton University, Princeton, New Jersey, United States of America

  ⨯
• María del Pilar Rodríguez-Ordoñez,

  Roles Investigation, Writing – review & editing

  Affiliation Department of Biological Sciences, Universidad de los Andes, Bogotá, Colombia

  https://orcid.org/0000-0002-0856-1297

  ⨯
• Karen Zhang,

  Roles Investigation

  Affiliation Department of Ecology and Evolution, Princeton University, Princeton, New Jersey, United States of America

  https://orcid.org/0000-0003-4406-9977

  ⨯
• Jay F. Storz,

  Roles Funding acquisition, Project administration, Supervision, Writing – review & editing

  Affiliation School of Biological Sciences, University of Nebraska, Lincoln, Nebraska, United States of America

  ⨯
• Susanne Dobler,

  Roles Funding acquisition, Project administration, Supervision, Writing – review & editing

  Affiliation Molecular Evolutionary Biology, Institut für Zell- und Systembiologie der Tiere, Universität Hamburg, Hamburg, Germany

  ⨯
• Andrew J. Crawford,

  Roles Conceptualization, Project administration, Supervision, Writing – review & editing

  Affiliation Department of Biological Sciences, Universidad de los Andes, Bogotá, Colombia

  https://orcid.org/0000-0003-3153-6898

  ⨯
• Peter Andolfatto

  Roles Conceptualization, Funding acquisition, Project administration, Supervision, Validation, Writing – original draft, Writing – review & editing

  * E-mail: pa2543@columbia.edu

  Affiliation Department of Biological Sciences, Columbia University, New York city, New York, United States of America

  https://orcid.org/0000-0003-3393-4574

  ⨯