Neurocognitive trajectory and proteomic signature of inherited risk for Alzheimer’s disease

• Manish D. Paranjpe,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

  https://orcid.org/0000-0002-6463-8965

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• Mark Chaffin,

  Roles Formal analysis

  Affiliation Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

  https://orcid.org/0000-0002-1234-5562

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• Sohail Zahid,

  Roles Formal analysis, Writing – original draft

  Affiliation Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

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• Scott Ritchie,

  Roles Supervision, Writing – review & editing

  Affiliations Cambridge Baker Systems Genomics Initiative, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom, Cambridge Baker Systems Genomics Initiative, Baker Heart & Diabetes Institute, Melbourne, Victoria, Australia, British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom, British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, United Kingdom, National Institute for Health Research Cambridge Biomedical Research Centre, University of Cambridge and Cambridge University Hospitals, Cambridge, United Kingdom

  https://orcid.org/0000-0002-8454-9548

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• Jerome I. Rotter,

  Roles Methodology, Supervision, Writing – review & editing

  Affiliation The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-University of California, Los Angeles Medical Center, Torrance, California, United States of America

  https://orcid.org/0000-0001-7191-1723

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• Stephen S. Rich,

  Roles Investigation, Supervision, Writing – review & editing

  Affiliation Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, United States of America

  https://orcid.org/0000-0003-3872-7793

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• Robert Gerszten,

  Roles Investigation, Supervision, Writing – review & editing

  Affiliations Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America, Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School

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• Xiuqing Guo,

  Roles Investigation, Supervision, Writing – review & editing

  Affiliation The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-University of California, Los Angeles Medical Center, Torrance, California, United States of America

  https://orcid.org/0000-0002-5264-5068

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• Susan Heckbert,

  Roles Investigation, Supervision, Writing – review & editing

  Affiliation Department of Epidemiology, University of Washington, Seattle, Washington, United States of America

  https://orcid.org/0000-0002-7100-512X

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• Russ Tracy,

  Roles Investigation, Supervision, Writing – review & editing

  Affiliation Department of Biochemistry, Larner College of Medicine, University of Vermont, Burlington, Vermont, United States of America

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• John Danesh,

  Roles Investigation, Supervision, Writing – review & editing

  Affiliations British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom, British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, United Kingdom, National Institute for Health Research Cambridge Biomedical Research Centre, University of Cambridge and Cambridge University Hospitals, Cambridge, United Kingdom, Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, United Kingdom, Department of Human Genetics, Wellcome Sanger Institute, Hinxton, United Kingdom, National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, United Kingdom

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• Eric S. Lander,

  Roles Conceptualization, Investigation, Supervision, Writing – review & editing

  Affiliations Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America

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• Michael Inouye,

  Roles Investigation, Supervision, Writing – review & editing

  Affiliations Cambridge Baker Systems Genomics Initiative, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom, Cambridge Baker Systems Genomics Initiative, Baker Heart & Diabetes Institute, Melbourne, Victoria, Australia, British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom, British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, United Kingdom, National Institute for Health Research Cambridge Biomedical Research Centre, University of Cambridge and Cambridge University Hospitals, Cambridge, United Kingdom, Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, United Kingdom, Department of Clinical Pathology, University of Melbourne, Parkville, Victoria, Australia, The Alan Turing Institute, London, United Kingdom

  https://orcid.org/0000-0001-9413-6520

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• Sekar Kathiresan,

  Roles Conceptualization, Investigation, Methodology, Supervision, Writing – review & editing

  Affiliations Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America, Verve Therapeutics, Cambridge, Massachusetts, United States of America, Division of Cardiology and Center for Genomic Medicine, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America

  https://orcid.org/0000-0002-3711-7101

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• Adam S. Butterworth,

  Roles Investigation, Supervision, Writing – review & editing

  Affiliations British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom, British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, United Kingdom, National Institute for Health Research Cambridge Biomedical Research Centre, University of Cambridge and Cambridge University Hospitals, Cambridge, United Kingdom, Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, United Kingdom, National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, United Kingdom

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•  [ ... ],
• Amit V. Khera

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Writing – original draft, Writing – review & editing

  * E-mail: avkhera@mgh.harvard.edu

  Affiliations Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America, Verve Therapeutics, Cambridge, Massachusetts, United States of America, Division of Cardiology and Center for Genomic Medicine, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America

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