Distinct developmental and degenerative functions of SARM1 require NAD+ hydrolase activity

E. J. Brace; Kow Essuman; Xianrong Mao; John Palucki; Yo Sasaki; Jeff Milbrandt; Aaron DiAntonio

doi:10.1371/journal.pgen.1010246

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Open Access

Peer-reviewed

Research Article

Distinct developmental and degenerative functions of SARM1 require NAD⁺ hydrolase activity

E. J. Brace,

Roles Conceptualization, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

Affiliation Department of Developmental Biology, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Kow Essuman,

Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – review & editing

Affiliation Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America

https://orcid.org/0000-0002-6781-7248

⨯
Xianrong Mao,

Roles Conceptualization, Investigation, Methodology, Writing – review & editing

Affiliation Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America

https://orcid.org/0000-0003-0449-2164

⨯
John Palucki,

Roles Conceptualization, Investigation, Methodology, Visualization

Affiliation Department of Developmental Biology, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Yo Sasaki,

Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – review & editing

Affiliation Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America

https://orcid.org/0000-0003-0024-0031

⨯
Jeff Milbrandt,

Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

Affiliations Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America, Needleman Center for Neurometabolism and Axonal Therapeutics, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Aaron DiAntonio

Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – review & editing

* E-mail: diantonio@wustl.edu

Affiliations Department of Developmental Biology, Washington University School of Medicine, St. Louis, Missouri, United States of America, Needleman Center for Neurometabolism and Axonal Therapeutics, Washington University School of Medicine, St. Louis, Missouri, United States of America

https://orcid.org/0000-0002-7262-0968

⨯

Distinct developmental and degenerative functions of SARM1 require NAD⁺ hydrolase activity

E. J. Brace,
Kow Essuman,
Xianrong Mao,
John Palucki,
Yo Sasaki,
Jeff Milbrandt,
Aaron DiAntonio

Published: June 23, 2022
https://doi.org/10.1371/journal.pgen.1010246

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