Inhibition of histone H3-H4 chaperone pathways rescues C. elegans sterility by H2B loss

Ruixue Zhao; Zhiwen Zhu; Ruxu Geng; Xuguang Jiang; Wei Li; Guangshuo Ou

doi:10.1371/journal.pgen.1010223

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Open Access

Peer-reviewed

Research Article

Inhibition of histone H3-H4 chaperone pathways rescues C. elegans sterility by H2B loss

Ruixue Zhao,

Roles Conceptualization, Formal analysis, Investigation, Validation, Writing – original draft, Writing – review & editing

Affiliation Tsinghua-Peking Center for Life Sciences, Beijing Frontier Research Center for Biological Structure, McGovern Institute for Brain Research, School of Life Sciences and MOE Key Laboratory for Protein Science, Tsinghua University, Beijing, China

https://orcid.org/0000-0001-9333-1287

⨯
Zhiwen Zhu,

Roles Investigation

Affiliation Tsinghua-Peking Center for Life Sciences, Beijing Frontier Research Center for Biological Structure, McGovern Institute for Brain Research, School of Life Sciences and MOE Key Laboratory for Protein Science, Tsinghua University, Beijing, China
⨯
Ruxu Geng,

Roles Formal analysis, Investigation

Affiliation Tsinghua-Peking Center for Life Sciences, Beijing Frontier Research Center for Biological Structure, McGovern Institute for Brain Research, School of Life Sciences and MOE Key Laboratory for Protein Science, Tsinghua University, Beijing, China
⨯
Xuguang Jiang,

Roles Investigation

Affiliation Tsinghua-Peking Center for Life Sciences, Beijing Frontier Research Center for Biological Structure, McGovern Institute for Brain Research, School of Life Sciences and MOE Key Laboratory for Protein Science, Tsinghua University, Beijing, China

https://orcid.org/0000-0001-7997-872X

⨯
Wei Li,

Roles Writing – review & editing

Affiliation School of Medicine, Tsinghua University, Beijing, China
⨯
Guangshuo Ou

Roles Conceptualization, Formal analysis, Funding acquisition, Supervision, Validation, Writing – original draft, Writing – review & editing

* E-mail: guangshuoou@tsinghua.edu.cn

Affiliation Tsinghua-Peking Center for Life Sciences, Beijing Frontier Research Center for Biological Structure, McGovern Institute for Brain Research, School of Life Sciences and MOE Key Laboratory for Protein Science, Tsinghua University, Beijing, China

https://orcid.org/0000-0003-1512-7824

⨯

Inhibition of histone H3-H4 chaperone pathways rescues C. elegans sterility by H2B loss

Ruixue Zhao,
Zhiwen Zhu,
Ruxu Geng,
Xuguang Jiang,
Wei Li,
Guangshuo Ou

Published: June 9, 2022
https://doi.org/10.1371/journal.pgen.1010223

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Histones
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Caenorhabditis elegans
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Fluorescence imaging
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Meiosis
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RNA interference
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