Abnormal global alternative RNA splicing in COVID-19 patients

Changli Wang; Lijun Chen; Yaobin Chen; Wenwen Jia; Xunhui Cai; Yufeng Liu; Fenghu Ji; Peng Xiong; Anyi Liang; Ren Liu; Yuanlin Guan; Zhongyi Cheng; Yejing Weng; Weixin Wang; Yaqi Duan; Dong Kuang; Sanpeng Xu; Hanghang Cai; Qin Xia; Dehua Yang; Ming-Wei Wang; Xiangping Yang; Jianjun Zhang; Chao Cheng; Liang Liu; Zhongmin Liu; Ren Liang; Guopin Wang; Zhendong Li; Han Xia; Tian Xia

doi:10.1371/journal.pgen.1010137

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Open Access

Peer-reviewed

Research Article

Abnormal global alternative RNA splicing in COVID-19 patients

Changli Wang ,

Contributed equally to this work with: Changli Wang, Lijun Chen

Roles Investigation, Methodology, Resources, Writing – original draft

Affiliation Department of Pathology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

https://orcid.org/0000-0002-1754-187X

⨯
Lijun Chen ,

Contributed equally to this work with: Changli Wang, Lijun Chen

Roles Formal analysis, Methodology, Validation

Affiliation Department of Pathology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

https://orcid.org/0000-0003-4518-4803

⨯
Yaobin Chen,

Roles Resources

Affiliation Institute of Artificial Intelligence and Automation, Huazhong University of Science and Technology, Wuhan, China
⨯
Wenwen Jia,

Roles Formal analysis

Affiliation Institute for Regenerative Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, China
⨯
Xunhui Cai,

Roles Formal analysis

Affiliation Institute of Artificial Intelligence and Automation, Huazhong University of Science and Technology, Wuhan, China

https://orcid.org/0000-0002-5213-5949

⨯
Yufeng Liu,

Roles Formal analysis

Affiliation Institute of Artificial Intelligence and Automation, Huazhong University of Science and Technology, Wuhan, China
⨯
Fenghu Ji,

Roles Formal analysis

Affiliation Institute of Artificial Intelligence and Automation, Huazhong University of Science and Technology, Wuhan, China
⨯
Peng Xiong,

Roles Visualization

Affiliation Institute of Artificial Intelligence and Automation, Huazhong University of Science and Technology, Wuhan, China

https://orcid.org/0000-0002-4606-4312

⨯
Anyi Liang,

Roles Validation

Affiliation Institute of Artificial Intelligence and Automation, Huazhong University of Science and Technology, Wuhan, China

https://orcid.org/0000-0003-1756-9407

⨯
Ren Liu,

Roles Data curation

Affiliation Department of Research and Development, Hugobiotech Co. Ltd., Beijing, China
⨯
Yuanlin Guan,

Roles Data curation

Affiliation Department of Research and Development, Hugobiotech Co. Ltd., Beijing, China
⨯
Zhongyi Cheng,

Roles Data curation

Affiliation Jingjie PTM BioLab (Hangzhou) Co. Ltd., Hangzhou, China

https://orcid.org/0000-0002-8764-2019

⨯
Yejing Weng,

Roles Data curation

Affiliation Jingjie PTM BioLab (Hangzhou) Co. Ltd., Hangzhou, China
⨯
Weixin Wang,

Roles Data curation

Affiliation Jingjie PTM BioLab (Hangzhou) Co. Ltd., Hangzhou, China
⨯
Yaqi Duan,

Roles Resources

Affiliation Institute of Artificial Intelligence and Automation, Huazhong University of Science and Technology, Wuhan, China
⨯
Dong Kuang,

Roles Resources

Affiliation Institute of Artificial Intelligence and Automation, Huazhong University of Science and Technology, Wuhan, China
⨯
Sanpeng Xu,

Roles Resources

Affiliation Institute of Artificial Intelligence and Automation, Huazhong University of Science and Technology, Wuhan, China
⨯
Hanghang Cai,

Roles Resources

Affiliation Institute of Artificial Intelligence and Automation, Huazhong University of Science and Technology, Wuhan, China
⨯
Qin Xia,

Roles Resources

Affiliation Department of Pathology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
⨯
Dehua Yang,

Roles Writing – review & editing

Affiliation The National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
⨯
Ming-Wei Wang,

Roles Writing – review & editing

Affiliation The National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
⨯
Xiangping Yang,

Roles Writing – review & editing

Affiliation Department of Pathology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
⨯
Jianjun Zhang,

Roles Writing – review & editing

Affiliations Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America, Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
⨯
Chao Cheng,

Roles Methodology, Writing – review & editing

Affiliation Department of Medicine, Baylor College of Medicine, Houston, Texas, United States of America
⨯
Liang Liu,

Roles Resources

Affiliation Department of Forensic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
⨯
Zhongmin Liu,

Roles Writing – review & editing

Affiliation Institute for Regenerative Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, China
⨯
Ren Liang,

Roles Writing – review & editing

Affiliation Department of Forensic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
⨯
Guopin Wang,

Roles Resources

Affiliation Institute of Artificial Intelligence and Automation, Huazhong University of Science and Technology, Wuhan, China
⨯
Zhendong Li ,

Roles Validation, Writing – review & editing

* E-mail: biolzd@foxmail.com (ZL); xiahan@hugobiotech.com (HX); tianxia@hust.edu.cn (TX)

Affiliation Elongevity INC, Wuhan, China
⨯
Han Xia ,

Roles Methodology, Validation

* E-mail: biolzd@foxmail.com (ZL); xiahan@hugobiotech.com (HX); tianxia@hust.edu.cn (TX)

Affiliations Department of Research and Development, Hugobiotech Co. Ltd., Beijing, China, School of Automation Science and Engineering, Faculty of Electronic and Information Engineering, Xi’an Jiaotong University, Xi’an, China
⨯
[ ... ],
Tian Xia

Roles Funding acquisition, Methodology, Supervision, Writing – review & editing

* E-mail: biolzd@foxmail.com (ZL); xiahan@hugobiotech.com (HX); tianxia@hust.edu.cn (TX)

Affiliations Department of Pathology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, Institute of Artificial Intelligence and Automation, Huazhong University of Science and Technology, Wuhan, China
⨯
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Abnormal global alternative RNA splicing in COVID-19 patients

Changli Wang,
Lijun Chen,
Yaobin Chen,
Wenwen Jia,
Xunhui Cai,
Yufeng Liu,
Fenghu Ji,
Peng Xiong,
Anyi Liang,
Ren Liu

Published: April 14, 2022
https://doi.org/10.1371/journal.pgen.1010137

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