RNA editing increases the nucleotide diversity of SARS-CoV-2 in human host cells

Xinxin Peng; Yikai Luo; Hongyue Li; Xuejiao Guo; Hu Chen; Xuwo Ji; Han Liang

doi:10.1371/journal.pgen.1010130

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Open Access

Peer-reviewed

Research Article

RNA editing increases the nucleotide diversity of SARS-CoV-2 in human host cells

Xinxin Peng ,

Contributed equally to this work with: Xinxin Peng, Yikai Luo

Roles Conceptualization, Formal analysis, Investigation, Project administration, Visualization, Writing – original draft, Writing – review & editing

Affiliation Precision Scientific (Beijing) Co., Ltd., Beijing, China

https://orcid.org/0000-0002-1503-5404

⨯
Yikai Luo ,

Contributed equally to this work with: Xinxin Peng, Yikai Luo

Roles Conceptualization, Formal analysis, Investigation, Visualization, Writing – original draft, Writing – review & editing

Affiliations Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America, Graduate Program in Quantitative and Computational Biosciences, Baylor College of Medicine, Houston, Texas, United States of America

https://orcid.org/0000-0001-7589-7981

⨯
Hongyue Li,

Roles Formal analysis, Investigation

Affiliation Precision Scientific (Beijing) Co., Ltd., Beijing, China

https://orcid.org/0000-0003-3028-4246

⨯
Xuejiao Guo,

Roles Formal analysis, Investigation

Affiliation Precision Scientific (Beijing) Co., Ltd., Beijing, China

https://orcid.org/0000-0001-9442-8718

⨯
Hu Chen,

Roles Formal analysis, Investigation

Affiliation Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America

https://orcid.org/0000-0001-5472-7158

⨯
Xuwo Ji,

Roles Funding acquisition, Resources

Affiliation Precision Scientific (Beijing) Co., Ltd., Beijing, China

https://orcid.org/0000-0002-5253-6523

⨯
Han Liang

Roles Conceptualization, Formal analysis, Investigation, Project administration, Resources, Supervision, Visualization, Writing – original draft, Writing – review & editing

* E-mail: hliang1@mdanderson.org

Affiliations Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America, Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America

https://orcid.org/0000-0001-7633-286X

⨯

RNA editing increases the nucleotide diversity of SARS-CoV-2 in human host cells

Xinxin Peng,
Yikai Luo,
Hongyue Li,
Xuejiao Guo,
Hu Chen,
Xuwo Ji,
Han Liang

Published: March 30, 2022
https://doi.org/10.1371/journal.pgen.1010130

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RNA editing
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SARS CoV 2
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COVID 19
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Nucleotide sequencing
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RNA structure
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