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Patient-derived iPSCs link elevated mitochondrial respiratory complex I function to osteosarcoma in Rothmund-Thomson syndrome
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Brittany E. Jewell,
Roles Conceptualization, Formal analysis, Investigation, Writing – original draft
Affiliations Department of Integrative Biology and Pharmacology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America, The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, Texas, United States of America
⨯ -
An Xu,
Roles Formal analysis, Investigation
Affiliation Department of Integrative Biology and Pharmacology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America
⨯ -
Dandan Zhu,
Roles Formal analysis, Investigation
Affiliation Department of Integrative Biology and Pharmacology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America
⨯ -
Mo-Fan Huang,
Roles Formal analysis, Investigation
Affiliations Department of Integrative Biology and Pharmacology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America, The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, Texas, United States of America
⨯ - Linchao Lu,
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Mo Liu,
Roles Investigation
Affiliation Department of Integrative Biology and Pharmacology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America
⨯ - Erica L. Underwood,
- Jun Hyoung Park,
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Huihui Fan,
Roles Investigation
Affiliation Center for Precision Health, School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America
⨯ - Julian A. Gingold,
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Ruoji Zhou,
Roles Investigation
Affiliation Department of Integrative Biology and Pharmacology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America
⨯ - Jian Tu,
- Zijun Huo,
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Ying Liu,
Roles Investigation
Affiliation Department of Integrative Biology and Pharmacology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America
⨯ - Weidong Jin,
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Yi-Hung Chen,
Roles Investigation
Affiliation Department and Institute of Pharmacology, National Yang Ming Chiao Tung University, Taipei, Taiwan
⨯ - Yitian Xu,
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Shu-Hsia Chen,
Roles Investigation
Affiliation Center for Immunotherapy Research, Cancer Center of Excellence, Houston Methodist Research Institute, Houston, Texas, United States of America
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Nino Rainusso,
Roles Investigation
Affiliation Department of Pediatrics, Baylor College of Medicine, Texas Children’s Hospital, Houston, Texas, United States of America
⨯ -
Nathaniel K. Berg,
Roles Investigation
Affiliations The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, Texas, United States of America, Department of Anesthesiology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America
⨯ - Danielle A. Bazer,
- Christopher Vellano,
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Philip Jones,
Roles Resources
Affiliation TRACTION Platform, Therapeutics Discovery Division, University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
⨯ -
Holger K. Eltzschig,
Roles Funding acquisition, Investigation
Affiliations The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, Texas, United States of America, Department of Anesthesiology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America
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Zhongming Zhao,
Roles Funding acquisition, Investigation
Affiliations The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, Texas, United States of America, Center for Precision Health, School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America
⨯ - Benny Abraham Kaipparettu,
- Ruiying Zhao,
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Lisa L. Wang ,
Contributed equally to this work with: Lisa L. Wang, Dung-Fang Lee
Roles Conceptualization, Formal analysis, Funding acquisition, Supervision, Validation, Writing – original draft, Writing – review & editing
* E-mail: llwang@bcm.edu (LLW); dung-fang.lee@uth.tmc.edu (D-FL)
Affiliation Department of Pediatrics, Baylor College of Medicine, Texas Children’s Hospital, Houston, Texas, United States of America
⨯ - [ ... ],
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Dung-Fang Lee
Contributed equally to this work with: Lisa L. Wang, Dung-Fang Lee
Roles Conceptualization, Formal analysis, Funding acquisition, Supervision, Validation, Writing – original draft, Writing – review & editing
* E-mail: llwang@bcm.edu (LLW); dung-fang.lee@uth.tmc.edu (D-FL)
Affiliations Department of Integrative Biology and Pharmacology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America, The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, Texas, United States of America, Center for Precision Health, School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America, Center for Stem Cell and Regenerative Medicine, The Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America
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https://orcid.org/0000-0003-4483-5053
Patient-derived iPSCs link elevated mitochondrial respiratory complex I function to osteosarcoma in Rothmund-Thomson syndrome
- Brittany E. Jewell,
- An Xu,
- Dandan Zhu,
- Mo-Fan Huang,
- Linchao Lu,
- Mo Liu,
- Erica L. Underwood,
- Jun Hyoung Park,
- Huihui Fan,
- Julian A. Gingold
- Published: December 29, 2021
- https://doi.org/10.1371/journal.pgen.1009971