Neuroplastin genetically interacts with Cadherin 23 and the encoded isoform Np55 is sufficient for cochlear hair cell function and hearing

Sherylanne Newton; Fanbo Kong; Adam J. Carlton; Carlos Aguilar; Andrew Parker; Gemma F. Codner; Lydia Teboul; Sara Wells; Steve D. M. Brown; Walter Marcotti; Michael R. Bowl

doi:10.1371/journal.pgen.1009937

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Peer-reviewed

Research Article

Neuroplastin genetically interacts with Cadherin 23 and the encoded isoform Np55 is sufficient for cochlear hair cell function and hearing

Sherylanne Newton,

Roles Conceptualization, Formal analysis, Investigation, Writing – original draft, Writing – review & editing

Affiliation Mammalian Genetics Unit, MRC Harwell Institute, Harwell Oxford, United Kingdom

https://orcid.org/0000-0002-8210-3526

⨯
Fanbo Kong,

Roles Formal analysis, Investigation, Writing – original draft, Writing – review & editing

Affiliation School of Sciences, University of Sheffield, Sheffield, United Kingdom

https://orcid.org/0000-0003-3029-5500

⨯
Adam J. Carlton,

Roles Formal analysis, Investigation, Writing – original draft, Writing – review & editing

Affiliation School of Sciences, University of Sheffield, Sheffield, United Kingdom

https://orcid.org/0000-0002-1054-3901

⨯
Carlos Aguilar,

Roles Formal analysis, Investigation, Writing – review & editing

Affiliation Mammalian Genetics Unit, MRC Harwell Institute, Harwell Oxford, United Kingdom

https://orcid.org/0000-0002-4655-1778

⨯
Andrew Parker,

Roles Formal analysis, Investigation, Writing – review & editing

Affiliation Mammalian Genetics Unit, MRC Harwell Institute, Harwell Oxford, United Kingdom
⨯
Gemma F. Codner,

Roles Formal analysis, Investigation, Writing – review & editing

Affiliation Mary Lyon Centre, MRC Harwell Institute, Harwell Oxford, United Kingdom
⨯
Lydia Teboul,

Roles Resources, Writing – review & editing

Affiliation Mary Lyon Centre, MRC Harwell Institute, Harwell Oxford, United Kingdom
⨯
Sara Wells,

Roles Resources, Writing – review & editing

Affiliation Mary Lyon Centre, MRC Harwell Institute, Harwell Oxford, United Kingdom

https://orcid.org/0000-0002-0572-0600

⨯
Steve D. M. Brown,

Roles Conceptualization, Funding acquisition, Writing – review & editing

Affiliation Mammalian Genetics Unit, MRC Harwell Institute, Harwell Oxford, United Kingdom
⨯
Walter Marcotti,

Roles Conceptualization, Formal analysis, Funding acquisition, Supervision, Writing – original draft, Writing – review & editing

Affiliations School of Sciences, University of Sheffield, Sheffield, United Kingdom, Sheffield Neuroscience Institute, University of Sheffield, Sheffield, United Kingdom

https://orcid.org/0000-0002-8770-7628

⨯
Michael R. Bowl

Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Supervision, Writing – original draft, Writing – review & editing

* E-mail: m.bowl@ucl.ac.uk

Affiliations Mammalian Genetics Unit, MRC Harwell Institute, Harwell Oxford, United Kingdom, UCL Ear Institute, University College London, London, United Kingdom

https://orcid.org/0000-0001-7971-445X

⨯

Neuroplastin genetically interacts with Cadherin 23 and the encoded isoform Np55 is sufficient for cochlear hair cell function and hearing

Sherylanne Newton,
Fanbo Kong,
Adam J. Carlton,
Carlos Aguilar,
Andrew Parker,
Gemma F. Codner,
Lydia Teboul,
Sara Wells,
Steve D. M. Brown,
Walter Marcotti

Published: January 31, 2022
https://doi.org/10.1371/journal.pgen.1009937
See the preprint

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