A large-scale transgenic RNAi screen identifies transcription factors that modulate myofiber size in Drosophila

Flavia A. Graca; Natalie Sheffield; Melissa Puppa; David Finkelstein; Liam C. Hunt; Fabio Demontis

doi:10.1371/journal.pgen.1009926

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Peer-reviewed

Research Article

A large-scale transgenic RNAi screen identifies transcription factors that modulate myofiber size in Drosophila

Flavia A. Graca,

Roles Conceptualization, Formal analysis, Investigation, Methodology, Resources, Visualization, Writing – review & editing

Affiliation Department of Developmental Neurobiology, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America

https://orcid.org/0000-0002-7342-6534

⨯
Natalie Sheffield,

Roles Conceptualization, Formal analysis, Investigation, Methodology, Resources

Affiliation Department of Developmental Neurobiology, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America

https://orcid.org/0000-0001-8947-113X

⨯
Melissa Puppa,

Roles Conceptualization, Investigation, Methodology, Resources, Writing – review & editing

Current address: College of Health Sciences, University of Memphis, Memphis, Tennessee, United States of America

Affiliation Department of Developmental Neurobiology, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America

https://orcid.org/0000-0003-3826-0003

⨯
David Finkelstein,

Roles Formal analysis, Investigation, Methodology

Affiliation Department of Computational Biology, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America
⨯
Liam C. Hunt,

Roles Conceptualization, Investigation, Methodology, Resources, Writing – review & editing

Affiliation Department of Developmental Neurobiology, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America

https://orcid.org/0000-0001-5192-1473

⨯
Fabio Demontis

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Visualization, Writing – original draft, Writing – review & editing

* E-mail: Fabio.Demontis@stjude.org

Affiliation Department of Developmental Neurobiology, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America

https://orcid.org/0000-0002-8698-9555

⨯

A large-scale transgenic RNAi screen identifies transcription factors that modulate myofiber size in Drosophila

Flavia A. Graca,
Natalie Sheffield,
Melissa Puppa,
David Finkelstein,
Liam C. Hunt,
Fabio Demontis

Published: November 15, 2021
https://doi.org/10.1371/journal.pgen.1009926

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RNA interference
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Skeletal muscles
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Larvae
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Transcription factors
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Drosophila melanogaster
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Transcriptional control
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Atrophy
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Regulator genes
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