Abnormal accumulation of lipid droplets in neurons induces the conversion of alpha-Synuclein to proteolytic resistant forms in a Drosophila model of Parkinson’s disease

• Victor Girard,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Laboratory of Biology and Modelling of the Cell, UMR5239 CNRS/ENS de Lyon, INSERM U1210, UMS 3444 Biosciences Lyon Gerland, University of Lyon, Lyon, France

  https://orcid.org/0000-0002-5743-9503

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• Florence Jollivet,

  Roles Data curation, Formal analysis, Investigation, Methodology

  Affiliation Laboratory of Biology and Modelling of the Cell, UMR5239 CNRS/ENS de Lyon, INSERM U1210, UMS 3444 Biosciences Lyon Gerland, University of Lyon, Lyon, France

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• Oskar Knittelfelder,

  Roles Conceptualization, Formal analysis, Methodology

  Affiliation Max-Planck-Institute of Molecular Cell Biology and Genetics, Dresden, Germany

  https://orcid.org/0000-0002-1565-7238

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• Marion Celle,

  Roles Investigation

  Affiliation Laboratory of Biology and Modelling of the Cell, UMR5239 CNRS/ENS de Lyon, INSERM U1210, UMS 3444 Biosciences Lyon Gerland, University of Lyon, Lyon, France

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• Jean-Noel Arsac,

  Roles Methodology

  Affiliation Neurodegenerative Disease Unit; French Agency for Food, Environmental and Occupational Health & Safety Laboratory (Anses) of Lyon, University of Lyon, Lyon, France

  https://orcid.org/0000-0002-8887-7282

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• Gilles Chatelain,

  Roles Investigation

  Affiliation Laboratory of Biology and Modelling of the Cell, UMR5239 CNRS/ENS de Lyon, INSERM U1210, UMS 3444 Biosciences Lyon Gerland, University of Lyon, Lyon, France

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• Daan M. Van den Brink,

  Roles Conceptualization

  Affiliations Laboratory of Biology and Modelling of the Cell, UMR5239 CNRS/ENS de Lyon, INSERM U1210, UMS 3444 Biosciences Lyon Gerland, University of Lyon, Lyon, France, Plant Systems Physiology, Radboud Institute for Biological and Environmental Sciences, Radboud University, Nijmegen, The Netherlands

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• Thierry Baron,

  Roles Methodology, Supervision

  Affiliation Neurodegenerative Disease Unit; French Agency for Food, Environmental and Occupational Health & Safety Laboratory (Anses) of Lyon, University of Lyon, Lyon, France

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• Andrej Shevchenko,

  Roles Funding acquisition, Methodology, Supervision

  Affiliation Max-Planck-Institute of Molecular Cell Biology and Genetics, Dresden, Germany

  https://orcid.org/0000-0002-5079-1109

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• Ronald P. Kühnlein,

  Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

  Affiliations Institute of Molecular Biosciences, University of Graz, Graz, Austria, BioTechMed-Graz, Graz, Austria, Field of Excellence BioHealth—University of Graz, Graz, Austria

  https://orcid.org/0000-0003-1448-4117

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• Nathalie Davoust ,

  Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: nathalie.davoust-nataf@ens-lyon.fr (ND); bertrand.mollereau@ens-lyon.fr (BM)

  ¶‡ These authors are co-senior authors on this work.

  Affiliation Laboratory of Biology and Modelling of the Cell, UMR5239 CNRS/ENS de Lyon, INSERM U1210, UMS 3444 Biosciences Lyon Gerland, University of Lyon, Lyon, France

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• Bertrand Mollereau

  Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Supervision, Writing – original draft

  * E-mail: nathalie.davoust-nataf@ens-lyon.fr (ND); bertrand.mollereau@ens-lyon.fr (BM)

  ¶‡ These authors are co-senior authors on this work.

  Affiliation Laboratory of Biology and Modelling of the Cell, UMR5239 CNRS/ENS de Lyon, INSERM U1210, UMS 3444 Biosciences Lyon Gerland, University of Lyon, Lyon, France

  https://orcid.org/0000-0003-4710-8185

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