A Bayesian network approach incorporating imputation of missing data enables exploratory analysis of complex causal biological relationships

Richard Howey; Alexander D. Clark; Najib Naamane; Louise N. Reynard; Arthur G. Pratt; Heather J. Cordell

doi:10.1371/journal.pgen.1009811

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Peer-reviewed

Research Article

A Bayesian network approach incorporating imputation of missing data enables exploratory analysis of complex causal biological relationships

Richard Howey,

Roles Formal analysis, Investigation, Methodology, Software, Writing – original draft

Affiliation Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, United Kingdom
⨯
Alexander D. Clark,

Roles Formal analysis, Investigation, Writing – review & editing

Affiliation Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom

https://orcid.org/0000-0003-4781-8531

⨯
Najib Naamane,

Roles Formal analysis, Investigation, Writing – review & editing

Affiliation Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom

https://orcid.org/0000-0001-8518-4811

⨯
Louise N. Reynard,

Roles Conceptualization, Supervision, Writing – review & editing

Affiliation Biosciences Institute, Newcastle University, Newcastle upon Tyne, United Kingdom
⨯
Arthur G. Pratt,

Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

Affiliations Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom, Musculoskeletal Services Directorate, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom

https://orcid.org/0000-0002-9909-8209

⨯
Heather J. Cordell

Roles Conceptualization, Funding acquisition, Methodology, Supervision, Writing – original draft

* E-mail: heather.cordell@newcastle.ac.uk

Affiliation Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, United Kingdom

https://orcid.org/0000-0002-1879-5572

⨯

A Bayesian network approach incorporating imputation of missing data enables exploratory analysis of complex causal biological relationships

Richard Howey,
Alexander D. Clark,
Najib Naamane,
Louise N. Reynard,
Arthur G. Pratt,
Heather J. Cordell

Published: September 29, 2021
https://doi.org/10.1371/journal.pgen.1009811

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