R-loops and regulatory changes in chronologically ageing fission yeast cells drive non-random patterns of genome rearrangements

• David A. Ellis,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Software, Visualization, Writing – original draft, Writing – review & editing

  Current address: Ear Institute, University College London, London, United Kingdom (D.A.E.); Department of Biology, University of York, York, United Kingdom (D.C.J)

  Affiliation Institute of Healthy Ageing, Department of Genetics, Evolution & Environment, University College London, London, United Kingdom

  https://orcid.org/0000-0002-3366-7712

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• Félix Reyes-Martín,

  Roles Investigation, Methodology

  Affiliation Centro Andaluz de Biología del Desarrollo, Universidad Pablo de Olavide/Consejo Superior de Investigaciones Científicas, Seville, Spain

  https://orcid.org/0000-0002-7046-9926

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• María Rodríguez-López,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliation Institute of Healthy Ageing, Department of Genetics, Evolution & Environment, University College London, London, United Kingdom

  https://orcid.org/0000-0002-2066-0589

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• Cristina Cotobal,

  Roles Investigation, Methodology

  Affiliation Institute of Healthy Ageing, Department of Genetics, Evolution & Environment, University College London, London, United Kingdom

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• Xi-Ming Sun,

  Roles Investigation, Methodology

  Affiliations MRC London Institute of Medical Sciences, London, United Kingdom, Institute of Clinical Sciences, Imperial College London, London, United Kingdom

  https://orcid.org/0000-0002-5796-6020

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• Quentin Saintain,

  Roles Investigation

  Affiliation Institute of Healthy Ageing, Department of Genetics, Evolution & Environment, University College London, London, United Kingdom

  https://orcid.org/0000-0003-0162-7625

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• Daniel C. Jeffares,

  Roles Resources, Supervision

  Current address: Ear Institute, University College London, London, United Kingdom (D.A.E.); Department of Biology, University of York, York, United Kingdom (D.C.J)

  Affiliation Institute of Healthy Ageing, Department of Genetics, Evolution & Environment, University College London, London, United Kingdom

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• Samuel Marguerat,

  Roles Funding acquisition, Methodology, Supervision, Writing – review & editing

  Affiliations MRC London Institute of Medical Sciences, London, United Kingdom, Institute of Clinical Sciences, Imperial College London, London, United Kingdom

  https://orcid.org/0000-0002-2402-3165

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• Víctor A. Tallada,

  Roles Methodology, Supervision, Writing – review & editing

  Affiliation Centro Andaluz de Biología del Desarrollo, Universidad Pablo de Olavide/Consejo Superior de Investigaciones Científicas, Seville, Spain

  https://orcid.org/0000-0001-9526-5957

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• Jürg Bähler

  Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: j.bahler@ucl.ac.uk

  Affiliation Institute of Healthy Ageing, Department of Genetics, Evolution & Environment, University College London, London, United Kingdom

  https://orcid.org/0000-0003-4036-1532

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