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Dyrk1a gene dosage in glutamatergic neurons has key effects in cognitive deficits observed in mouse models of MRD7 and Down syndrome
- Véronique Brault,
- Thu Lan Nguyen,
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Javier Flores-Gutiérrez,
Roles Formal analysis, Investigation
Affiliation Université de Strasbourg, CNRS, INSERM, Institut de Génétique et de Biologie Moléculaire et Cellulaire, IGBMC, Illkirch, France
⨯ - Giovanni Iacono,
- Marie-Christine Birling,
- Valérie Lalanne,
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Hamid Meziane,
Roles Investigation, Methodology
Affiliation Université de Strasbourg, CNRS, INSERM, CELPHEDIA, PHENOMIN, Institut Clinique de la Souris, Illkirch, France
⨯ - Antigoni Manousopoulou,
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Guillaume Pavlovic,
Roles Investigation, Methodology, Writing – original draft
Affiliation Université de Strasbourg, CNRS, INSERM, CELPHEDIA, PHENOMIN, Institut Clinique de la Souris, Illkirch, France
⨯ -
Loïc Lindner,
Roles Investigation, Methodology, Writing – original draft
Affiliation Université de Strasbourg, CNRS, INSERM, CELPHEDIA, PHENOMIN, Institut Clinique de la Souris, Illkirch, France
⨯ - Mohammed Selloum,
- Tania Sorg,
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Eugene Yu,
Roles Resources, Writing – original draft
Affiliations The Children’s Guild Foundation Down Syndrome Research Program, Genetics and Genomics Program and Department of Cancer Genetics and Genomics, Roswell Park Comprehensive Cancer Center, Buffalo, New York, United States of America, Genetics, Genomics and Bioinformatics Program, State University of New York At Buffalo, Buffalo, New York, United States of America
⨯ -
Spiros D. Garbis,
Roles Investigation, Methodology, Validation, Writing – original draft
Current address: Proteas Bioanalytics Inc., BioLabs at The Lundquist Institute, Torrance, California, United States of America
Affiliation Institute for Life Sciences, University of Southampton, School of Medicine, Southampton, United Kingdom
⨯ -
Yann Hérault
Roles Conceptualization, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing
* E-mail: herault@igbmc.fr
Affiliations Université de Strasbourg, CNRS, INSERM, Institut de Génétique et de Biologie Moléculaire et Cellulaire, IGBMC, Illkirch, France, Université de Strasbourg, CNRS, INSERM, CELPHEDIA, PHENOMIN, Institut Clinique de la Souris, Illkirch, France
⨯
https://orcid.org/0000-0002-5094-7978
Dyrk1a gene dosage in glutamatergic neurons has key effects in cognitive deficits observed in mouse models of MRD7 and Down syndrome
- Véronique Brault,
- Thu Lan Nguyen,
- Javier Flores-Gutiérrez,
- Giovanni Iacono,
- Marie-Christine Birling,
- Valérie Lalanne,
- Hamid Meziane,
- Antigoni Manousopoulou,
- Guillaume Pavlovic,
- Loïc Lindner
- Published: September 29, 2021
- https://doi.org/10.1371/journal.pgen.1009777