c-Jun N-terminal kinase (JNK) signaling contributes to cystic burden in polycystic kidney disease

Abigail O. Smith; Julie A. Jonassen; Kenley M. Preval; Roger J. Davis; Gregory J. Pazour

doi:10.1371/journal.pgen.1009711

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Open Access

Peer-reviewed

Research Article

c-Jun N-terminal kinase (JNK) signaling contributes to cystic burden in polycystic kidney disease

Abigail O. Smith,

Roles Conceptualization, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

Affiliation Program in Molecular Medicine, University of Massachusetts Chan Medical School, Biotech II, Worcester, Massachusetts, United States of America

https://orcid.org/0000-0003-2765-8737

⨯
Julie A. Jonassen,

Roles Investigation, Writing – review & editing

Affiliation Department of Microbiology and Physiological Systems, University of Massachusetts Chan Medical School, Worcester Massachusetts, United States of America
⨯
Kenley M. Preval,

Roles Investigation, Writing – review & editing

Affiliation Program in Molecular Medicine, University of Massachusetts Chan Medical School, Biotech II, Worcester, Massachusetts, United States of America

https://orcid.org/0000-0002-2425-0878

⨯
Roger J. Davis,

Roles Conceptualization, Funding acquisition, Resources, Writing – review & editing

Affiliation Program in Molecular Medicine, University of Massachusetts Chan Medical School, Biotech II, Worcester, Massachusetts, United States of America

https://orcid.org/0000-0002-0130-1652

⨯
Gregory J. Pazour

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Supervision, Writing – original draft, Writing – review & editing

* E-mail: gregory.pazour@umassmed.edu

Affiliation Program in Molecular Medicine, University of Massachusetts Chan Medical School, Biotech II, Worcester, Massachusetts, United States of America

https://orcid.org/0000-0002-6285-8796

⨯

c-Jun N-terminal kinase (JNK) signaling contributes to cystic burden in polycystic kidney disease

Abigail O. Smith,
Julie A. Jonassen,
Kenley M. Preval,
Roger J. Davis,
Gregory J. Pazour

Published: December 28, 2021
https://doi.org/10.1371/journal.pgen.1009711

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Kidneys
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c-Jun N-terminal kinase signaling cascade
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Mouse models
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Fibrosis
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Weight loss
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Phosphorylation
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Immunoblotting
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Polycystic kidney disease
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