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Open Access
Peer-reviewed
Research Article
Pleiotropy method reveals genetic overlap between orofacial clefts at multiple novel loci from GWAS of multi-ethnic trios
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Debashree Ray ,
Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing
* E-mail: dray@jhu.edu (DR); tbeaty1@jhu.edu (THB)
Affiliations Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America, Department of Biostatistics, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America
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Sowmya Venkataraghavan,
Roles Data curation, Formal analysis, Software, Validation, Visualization, Writing – review & editing
Affiliation Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America
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Wanying Zhang,
Roles Data curation, Formal analysis, Software, Writing – review & editing
Affiliation Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America
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Elizabeth J. Leslie,
Roles Investigation, Validation, Writing – review & editing
Affiliation Department of Human Genetics, School of Medicine, Emory University, Atlanta, Georgia, United States of America
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Jacqueline B. Hetmanski,
Roles Data curation, Writing – review & editing
Affiliation Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America
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Seth M. Weinberg,
Roles Resources, Writing – review & editing
Affiliations Department of Oral Biology, School of Dental Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Center for Craniofacial and Dental Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
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Jeffrey C. Murray,
Roles Resources
Affiliation Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, Iowa, United States of America
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Mary L. Marazita,
Roles Resources, Writing – review & editing
Affiliations Department of Oral Biology, School of Dental Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Center for Craniofacial and Dental Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
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Ingo Ruczinski,
Roles Investigation, Methodology, Writing – review & editing
Affiliation Department of Biostatistics, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America
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Margaret A. Taub,
Roles Investigation, Validation, Writing – review & editing
Affiliation Department of Biostatistics, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America
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Terri H. Beaty
Roles Conceptualization, Investigation, Project administration, Resources, Supervision, Writing – review & editing
* E-mail: dray@jhu.edu (DR); tbeaty1@jhu.edu (THB)
Affiliations Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America, Department of Biostatistics, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America
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Pleiotropy method reveals genetic overlap between orofacial clefts at multiple novel loci from GWAS of multi-ethnic trios
- Debashree Ray,
- Sowmya Venkataraghavan,
- Wanying Zhang,
- Elizabeth J. Leslie,
- Jacqueline B. Hetmanski,
- Seth M. Weinberg,
- Jeffrey C. Murray,
- Mary L. Marazita,
- Ingo Ruczinski,
- Margaret A. Taub
- Published: July 9, 2021
- https://doi.org/10.1371/journal.pgen.1009584