CRISPR/Cas9 modified An. gambiae carrying kdr mutation L1014F functionally validate its contribution in insecticide resistance and combined effect with metabolic enzymes

Linda Grigoraki; Ruth Cowlishaw; Tony Nolan; Martin Donnelly; Gareth Lycett; Hilary Ranson

doi:10.1371/journal.pgen.1009556

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Open Access

Peer-reviewed

Research Article

CRISPR/Cas9 modified An. gambiae carrying kdr mutation L1014F functionally validate its contribution in insecticide resistance and combined effect with metabolic enzymes

Linda Grigoraki ,

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Writing – original draft

* E-mail: Linta.Grigoraki@lstmed.ac.uk (LG); Hilary.Ranson@lstmed.ac.uk (HR)

Affiliation Vector Biology Department, Liverpool School of Tropical Medicine, Liverpool, United Kingdom

https://orcid.org/0000-0001-8997-0406

⨯
Ruth Cowlishaw,

Roles Investigation, Methodology, Writing – review & editing

Affiliation Vector Biology Department, Liverpool School of Tropical Medicine, Liverpool, United Kingdom

https://orcid.org/0000-0003-2673-5104

⨯
Tony Nolan,

Roles Resources, Writing – review & editing

Affiliation Vector Biology Department, Liverpool School of Tropical Medicine, Liverpool, United Kingdom

https://orcid.org/0000-0002-2982-8333

⨯
Martin Donnelly,

Roles Conceptualization, Writing – review & editing

Affiliation Vector Biology Department, Liverpool School of Tropical Medicine, Liverpool, United Kingdom

https://orcid.org/0000-0001-5218-1497

⨯
Gareth Lycett,

Roles Methodology, Resources, Writing – review & editing

Affiliation Vector Biology Department, Liverpool School of Tropical Medicine, Liverpool, United Kingdom

https://orcid.org/0000-0002-2422-053X

⨯
Hilary Ranson

Roles Conceptualization, Writing – original draft

* E-mail: Linta.Grigoraki@lstmed.ac.uk (LG); Hilary.Ranson@lstmed.ac.uk (HR)

Affiliation Vector Biology Department, Liverpool School of Tropical Medicine, Liverpool, United Kingdom

https://orcid.org/0000-0003-2332-8247

⨯

CRISPR/Cas9 modified An. gambiae carrying kdr mutation L1014F functionally validate its contribution in insecticide resistance and combined effect with metabolic enzymes

Linda Grigoraki,
Ruth Cowlishaw,
Tony Nolan,
Martin Donnelly,
Gareth Lycett,
Hilary Ranson

Published: July 6, 2021
https://doi.org/10.1371/journal.pgen.1009556

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Insecticides
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Mosquitoes
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Death rates
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DDT
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Larvae
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Detoxification
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Heterozygosity
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