Novel EDGE encoding method enhances ability to identify genetic interactions

• Molly A. Hall ,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – original draft, Writing – review & editing

  * E-mail: mah546@psu.edu

  Affiliations Department of Veterinary and Biomedical Sciences, College of Agricultural Sciences, The Pennsylvania State University, University Park, Pennsylvania, United States of America, Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, Pennsylvania, United States of America, Penn State Cancer Institute, The Pennsylvania State University, University Park, Pennsylvania, United States of America

  https://orcid.org/0000-0001-7740-401X

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• John Wallace,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Visualization

  Affiliation Department of Veterinary and Biomedical Sciences, College of Agricultural Sciences, The Pennsylvania State University, University Park, Pennsylvania, United States of America

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• Anastasia M. Lucas,

  Roles Formal analysis, Investigation, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Genetics, Institute for Biomedical Informatics, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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• Yuki Bradford,

  Roles Data curation, Formal analysis

  Affiliation Department of Genetics, Institute for Biomedical Informatics, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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• Shefali S. Verma,

  Roles Conceptualization, Data curation, Methodology, Writing – review & editing

  Affiliation Department of Genetics, Institute for Biomedical Informatics, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

  https://orcid.org/0000-0001-5216-4670

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• Bertram Müller-Myhsok,

  Roles Conceptualization, Methodology, Writing – review & editing

  Affiliations Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany, Munich Cluster for Systems Neurology (SyNergy), Munich, Germany, Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom

  https://orcid.org/0000-0002-0719-101X

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• Kristin Passero,

  Roles Writing – original draft, Writing – review & editing

  Affiliation Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, Pennsylvania, United States of America

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• Jiayan Zhou,

  Roles Writing – original draft, Writing – review & editing

  Affiliation Department of Veterinary and Biomedical Sciences, College of Agricultural Sciences, The Pennsylvania State University, University Park, Pennsylvania, United States of America

  https://orcid.org/0000-0001-5974-087X

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• John McGuigan,

  Roles Formal analysis, Validation

  Affiliation Department of Veterinary and Biomedical Sciences, College of Agricultural Sciences, The Pennsylvania State University, University Park, Pennsylvania, United States of America

  https://orcid.org/0000-0003-4149-875X

  ⨯
• Beibei Jiang,

  Roles Formal analysis

  Affiliations Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany, Munich Cluster for Systems Neurology (SyNergy), Munich, Germany, Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom

  https://orcid.org/0000-0002-8290-4622

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• Sarah A. Pendergrass,

  Roles Conceptualization, Writing – review & editing

  Affiliation Genentech, San Francisco, California, United States of America

  https://orcid.org/0000-0002-0565-6522

  ⨯
• Yanfei Zhang,

  Roles Writing – review & editing

  Affiliation Genomic Medicine Institute, Geisinger Health System, Danville, Pennsylvania, United States of America

  https://orcid.org/0000-0002-9222-7725

  ⨯
• Peggy Peissig,

  Roles Writing – review & editing

  Affiliation Center for Precision Medicine Research, Marshfield Clinic Research Institute, Marshfield, Wisconsin, United States of America

  ⨯
• Murray Brilliant,

  Roles Resources, Writing – review & editing

  Affiliation Center for Precision Medicine Research, Marshfield Clinic Research Institute, Marshfield, Wisconsin, United States of America

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• Patrick Sleiman,

  Roles Resources, Writing – review & editing

  Affiliation Department of Pediatrics, Center for Applied Genomics, Children’s Hospital of Pennsylvania, Philadelphia, Pennsylvania, United States of America

  https://orcid.org/0000-0001-9874-8532

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• Hakon Hakonarson,

  Roles Resources, Writing – review & editing

  Affiliation Department of Pediatrics, Center for Applied Genomics, Children’s Hospital of Pennsylvania, Philadelphia, Pennsylvania, United States of America

  https://orcid.org/0000-0003-2814-7461

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• John B. Harley,

  Roles Resources, Writing – review & editing

  Affiliations Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, United States of America, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America, United States Department of Veterans Affairs Medical Center, Cincinnati, Ohio, United States of America

  https://orcid.org/0000-0002-8463-1939

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• Krzysztof Kiryluk,

  Roles Resources, Writing – review & editing

  Affiliation Division of Nephrology, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York, United States of America

  https://orcid.org/0000-0002-5047-6715

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• Kristel Van Steen ,

  Roles Conceptualization, Methodology, Supervision, Writing – review & editing

  ¶‡ These authors are joint senior authors on this work.

  Affiliations WELBIO, GIGA-R Medical Genomics-BIO3, University of Liège, Liège, Belgium, Department of Human Genetics, University of Leuven, Leuven, Belgium

  https://orcid.org/0000-0001-9868-5033

  ⨯
• Jason H. Moore ,

  Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Writing – review & editing

  ¶‡ These authors are joint senior authors on this work.

  Affiliation Department of Genetics, Institute for Biomedical Informatics, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

  https://orcid.org/0000-0002-5015-1099

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•  [ ... ],
• Marylyn D. Ritchie

  Roles Conceptualization, Funding acquisition, Methodology, Project administration, Resources, Software, Supervision, Writing – review & editing

  ¶‡ These authors are joint senior authors on this work.

  Affiliation Department of Genetics, Institute for Biomedical Informatics, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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