Expression of the cancer-associated DNA polymerase ε P286R in fission yeast leads to translesion synthesis polymerase dependent hypermutation and defective DNA replication

• Ignacio Soriano ,

  Roles Data curation, Formal analysis, Investigation, Methodology, Resources, Validation, Visualization, Writing – original draft

  * E-mail: ignacio.soriano@igmm.ed.ac.uk (IS); stephen.kearsey@zoo.ox.ac.uk (SEK)

  Affiliations ZRAB, University of Oxford, Oxford, United Kingdom, Edinburgh Cancer Research Centre, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom

  https://orcid.org/0000-0002-7928-3511

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• Enrique Vazquez,

  Roles Data curation, Formal analysis, Resources, Software

  Affiliation Genomics Unit, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain

  https://orcid.org/0000-0003-1157-2592

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• Nagore De Leon ,

  Contributed equally to this work with: Nagore De Leon, Sibyl Bertrand

  Roles Investigation, Methodology

  Affiliations ZRAB, University of Oxford, Oxford, United Kingdom, Edinburgh Cancer Research Centre, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom

  https://orcid.org/0000-0002-3524-9557

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• Sibyl Bertrand ,

  Contributed equally to this work with: Nagore De Leon, Sibyl Bertrand

  Roles Investigation, Validation

  Affiliation ZRAB, University of Oxford, Oxford, United Kingdom

  https://orcid.org/0000-0001-8258-2099

  ⨯
• Ellen Heitzer,

  Roles Formal analysis, Investigation

  Affiliation Institute of Human Genetics, Diagnostic & Research Center for Molecular BioMedicine, Medical University of Graz, Graz, Austria

  https://orcid.org/0000-0002-8815-7859

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• Sophia Toumazou,

  Roles Investigation

  Affiliations ZRAB, University of Oxford, Oxford, United Kingdom, MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, United Kingdom

  https://orcid.org/0000-0001-5365-8285

  ⨯
• Zhihan Bo,

  Roles Investigation

  Affiliation ZRAB, University of Oxford, Oxford, United Kingdom

  https://orcid.org/0000-0002-1954-4580

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• Claire Palles,

  Roles Resources

  Affiliation Gastrointestinal Cancer Genetics Laboratory, Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom

  https://orcid.org/0000-0002-9670-2263

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• Chen-Chun Pai,

  Roles Investigation

  Affiliation MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, United Kingdom

  https://orcid.org/0000-0002-0368-7843

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• Timothy C. Humphrey,

  Roles Supervision

  Affiliation MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, United Kingdom

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• Ian Tomlinson,

  Roles Conceptualization, Funding acquisition

  Affiliation Edinburgh Cancer Research Centre, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom

  https://orcid.org/0000-0003-3037-1470

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• Sue Cotterill,

  Roles Conceptualization, Funding acquisition

  Affiliation St. George’s, University of London, Cranmer Terrace, Tooting, London, United Kingdom

  https://orcid.org/0000-0001-9913-0259

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• Stephen E. Kearsey

  Roles Conceptualization, Funding acquisition, Methodology, Project administration, Supervision, Visualization, Writing – review & editing

  * E-mail: ignacio.soriano@igmm.ed.ac.uk (IS); stephen.kearsey@zoo.ox.ac.uk (SEK)

  Affiliation ZRAB, University of Oxford, Oxford, United Kingdom

  https://orcid.org/0000-0002-3339-2667

  ⨯