Using genetic variants to evaluate the causal effect of cholesterol lowering on head and neck cancer risk: A Mendelian randomization study

• Mark Gormley ,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: mark.gormley@bristol.ac.uk

  Affiliations MRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom, Bristol Dental Hospital and School, University of Bristol, Bristol, United Kingdom, Department of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom

  https://orcid.org/0000-0001-5733-6304

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• James Yarmolinsky ,

  Contributed equally to this work with: James Yarmolinsky, Tom Dudding, Emma E. Vincent, Rebecca C. Richmond

  Roles Methodology, Writing – original draft, Writing – review & editing

  Affiliations MRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom, Department of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom

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• Tom Dudding ,

  Contributed equally to this work with: James Yarmolinsky, Tom Dudding, Emma E. Vincent, Rebecca C. Richmond

  Roles Methodology, Writing – original draft, Writing – review & editing

  Affiliations MRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom, Bristol Dental Hospital and School, University of Bristol, Bristol, United Kingdom, Department of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom

  https://orcid.org/0000-0003-3756-040X

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• Kimberley Burrows,

  Roles Formal analysis, Methodology, Writing – original draft, Writing – review & editing

  Affiliations MRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom, Department of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom

  https://orcid.org/0000-0002-3208-0389

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• Richard M. Martin,

  Roles Methodology, Writing – original draft, Writing – review & editing

  Affiliations MRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom, Department of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom, National Institute for Health Research Bristol Biomedical Research Centre at the University Hospitals Bristol and Weston NHS Foundation Trust, University of Bristol, Bristol, United Kingdom

  https://orcid.org/0000-0002-7992-7719

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• Steven Thomas,

  Roles Resources, Writing – review & editing

  Affiliations Bristol Dental Hospital and School, University of Bristol, Bristol, United Kingdom, National Institute for Health Research Bristol Biomedical Research Centre at the University Hospitals Bristol and Weston NHS Foundation Trust, University of Bristol, Bristol, United Kingdom

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• Jessica Tyrrell,

  Roles Methodology, Supervision, Writing – review & editing

  Affiliation University of Exeter Medical School, RILD Building, RD&E Hospital, Exeter, United Kingdom

  https://orcid.org/0000-0002-9256-6065

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• Paul Brennan,

  Roles Writing – review & editing

  Affiliation Genetic Epidemiology Group, World Health Organization, International Agency for Research on Cancer, Lyon, France

  https://orcid.org/0000-0002-0518-8714

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• Miranda Pring,

  Roles Resources, Writing – original draft, Writing – review & editing

  Affiliation Bristol Dental Hospital and School, University of Bristol, Bristol, United Kingdom

  ⨯
• Stefania Boccia,

  Roles Resources, Writing – review & editing

  Affiliations Section of Hygiene, University Department of Life Sciences and Public Health, Università Cattolica del Sacro Cuore, Roma, Italia, Department of Woman and Child Health and Public Health, Public Health Area, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy

  https://orcid.org/0000-0002-1864-749X

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• Andrew F. Olshan,

  Roles Resources, Writing – review & editing

  Affiliation Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, United States of America

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• Brenda Diergaarde,

  Roles Methodology, Resources, Writing – original draft, Writing – review & editing

  Affiliation Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, and UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania, United States of America

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• Rayjean J. Hung,

  Roles Resources, Writing – review & editing

  Affiliations Prosserman Centre for Population Health Research, Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Canada, Dalla Lana School of Public Health, University of Toronto, Toronto, Canada

  https://orcid.org/0000-0002-4486-7496

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• Geoffrey Liu,

  Roles Resources, Writing – review & editing

  Affiliations Dalla Lana School of Public Health, University of Toronto, Toronto, Canada, Princess Margaret Cancer Centre, Toronto, Canada

  ⨯
• Danny Legge,

  Roles Writing – review & editing

  Affiliation School of Cellular and Molecular Medicine, University of Bristol, Bristol, United Kingdom

  https://orcid.org/0000-0002-3897-5861

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• Eloiza H. Tajara,

  Roles Resources, Writing – review & editing

  Affiliation School of Medicine of São José do Rio Preto, São Paulo, Brazil

  https://orcid.org/0000-0002-2603-2057

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• Patricia Severino,

  Roles Resources, Writing – review & editing

  Affiliation Albert Einstein Research and Education Institute, Hospital Israelita Albert Einstein, São Paulo, Brazil

  https://orcid.org/0000-0002-6682-9343

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• Martin Lacko,

  Roles Resources, Writing – review & editing

  Affiliation Department of Otorhinolaryngology and Head and Neck Surgery, Research Institute GROW, Maastricht University Medical Center, Maastricht, The Netherlands

  https://orcid.org/0000-0003-2868-4822

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• Andrew R. Ness,

  Roles Methodology, Supervision, Writing – original draft, Writing – review & editing

  Affiliation National Institute for Health Research Bristol Biomedical Research Centre at the University Hospitals Bristol and Weston NHS Foundation Trust, University of Bristol, Bristol, United Kingdom

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• George Davey Smith,

  Roles Methodology, Supervision, Writing – original draft, Writing – review & editing

  Affiliations MRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom, Department of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom

  https://orcid.org/0000-0002-1407-8314

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• Emma E. Vincent ,

  Contributed equally to this work with: James Yarmolinsky, Tom Dudding, Emma E. Vincent, Rebecca C. Richmond

  Roles Conceptualization, Supervision, Writing – original draft, Writing – review & editing

  Affiliations MRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom, Department of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom, School of Cellular and Molecular Medicine, University of Bristol, Bristol, United Kingdom

  https://orcid.org/0000-0002-8917-7384

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•  [ ... ],
• Rebecca C. Richmond

  Contributed equally to this work with: James Yarmolinsky, Tom Dudding, Emma E. Vincent, Rebecca C. Richmond

  Roles Conceptualization, Formal analysis, Methodology, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations MRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom, Department of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom

  https://orcid.org/0000-0003-0574-5071

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