Novel Variance-Component TWAS method for studying complex human diseases with applications to Alzheimer’s dementia

• Shizhen Tang,

  Roles Data curation, Formal analysis, Methodology, Software, Writing – original draft

  Affiliations Center for Computational and Quantitative Genetics, Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia, United States of America, Department of Biostatistics and Bioinformatics, Emory University School of Public Health, Atlanta, Georgia, United States of America

  https://orcid.org/0000-0002-2315-3638

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• Aron S. Buchman,

  Roles Data curation, Writing – review & editing

  Affiliation Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, Illinois, United States of America

  https://orcid.org/0000-0002-6426-2742

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• Philip L. De Jager,

  Roles Data curation

  Affiliation Center for Translational and Computational Neuroimmunology, Department of Neurology and Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Columbia University Irving Medical Center, New York, New York, United States of America

  https://orcid.org/0000-0002-8057-2505

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• David A. Bennett,

  Roles Data curation, Writing – review & editing

  Affiliation Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, Illinois, United States of America

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• Michael P. Epstein,

  Roles Conceptualization, Methodology, Writing – review & editing

  Affiliation Center for Computational and Quantitative Genetics, Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia, United States of America

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• Jingjing Yang

  Roles Conceptualization, Funding acquisition, Methodology, Writing – review & editing

  * E-mail: jingjing.yang@emory.edu

  Affiliation Center for Computational and Quantitative Genetics, Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia, United States of America

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