Tissue specificity-aware TWAS (TSA-TWAS) framework identifies novel associations with metabolic, immunologic, and virologic traits in HIV-positive adults

• Binglan Li,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Visualization, Writing – original draft

  Affiliation Department of Biomedical Data Science, Stanford University, Stanford, California, United States of America

  https://orcid.org/0000-0002-0103-6107

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• Yogasudha Veturi,

  Roles Methodology, Writing – review & editing

  Affiliation Department of Genetics, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

  https://orcid.org/0000-0002-5878-2960

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• Anurag Verma,

  Roles Data curation, Writing – review & editing

  Affiliation Department of Genetics, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

  https://orcid.org/0000-0002-5063-9107

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• Yuki Bradford,

  Roles Data curation, Writing – review & editing

  Affiliation Department of Genetics, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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• Eric S. Daar,

  Roles Resources, Writing – review & editing

  Affiliation Lundquist Institute at Harbor-UCLA Medical Center, Torrance, California, United States of America

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• Roy M. Gulick,

  Roles Resources, Writing – review & editing

  Affiliation Weill Cornell Medicine, New York City, New York, United States of America

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• Sharon A. Riddler,

  Roles Resources, Writing – review & editing

  Affiliation Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

  https://orcid.org/0000-0002-2545-7037

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• Gregory K. Robbins,

  Roles Resources, Writing – review & editing

  Affiliation Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, United States of America

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• Jeffrey L. Lennox,

  Roles Resources, Writing – review & editing

  Affiliation Emory University School of Medicine, Atlanta, Georgia, United States of America

  https://orcid.org/0000-0002-2064-5565

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• David W. Haas,

  Roles Data curation, Funding acquisition, Resources, Writing – review & editing

  Affiliations Departments of Medicine, Pharmacology, Pathology, Microbiology & Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America, Department of Internal Medicine, Meharry Medical College, Nashville, Tennessee, United States of America

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• Marylyn D. Ritchie

  Roles Conceptualization, Funding acquisition, Investigation, Resources, Supervision, Writing – review & editing

  * E-mail: marylyn@pennmedicine.upenn.edu

  Affiliations Department of Genetics, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Institute for Biomedical Informatics, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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