The etiology of Down syndrome: Maternal MCM9 polymorphisms increase risk of reduced recombination and nondisjunction of chromosome 21 during meiosis I within oocyte

Upamanyu Pal; Pinku Halder; Anirban Ray; Sumantra Sarkar; Supratim Datta; Papiya Ghosh; Sujay Ghosh

doi:10.1371/journal.pgen.1009462

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Peer-reviewed

Research Article

The etiology of Down syndrome: Maternal MCM9 polymorphisms increase risk of reduced recombination and nondisjunction of chromosome 21 during meiosis I within oocyte

Upamanyu Pal,

Roles Data curation, Formal analysis, Methodology, Writing – original draft

Affiliation Cytogenetics and Genomics Research Unit, Department of Zoology, University of Calcutta, Taraknath Palit Siksha Prangan (Ballygunge Science College Campus), Kolkata, West Bengal, India
⨯
Pinku Halder,

Roles Formal analysis

Affiliation Cytogenetics and Genomics Research Unit, Department of Zoology, University of Calcutta, Taraknath Palit Siksha Prangan (Ballygunge Science College Campus), Kolkata, West Bengal, India
⨯
Anirban Ray,

Roles Formal analysis

Affiliation Department of Zoology, Bangabasi Morning College (affiliated to University of Calcutta), Kolkata, West Bengal, India
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Sumantra Sarkar,

Roles Data curation, Investigation

Affiliations Department of Paediatric Medicine, Institute of Post Graduate Medical Education and Research (IPGMER), Bhowanipore, Kolkata, West Bengal, India, Department of Paediatric Medicine, Diamond Harbour Government Medical College & Hospital, Diamond Harbour, West Bengal, India
⨯
Supratim Datta,

Roles Data curation, Investigation

Affiliation Department of Paediatric Medicine, Institute of Post Graduate Medical Education and Research (IPGMER), Bhowanipore, Kolkata, West Bengal, India
⨯
Papiya Ghosh,

Roles Formal analysis, Writing – original draft

Affiliation Department of Zoology, Bijoykrishna Girls’ College (Affiliated to University of Calcutta), Howrah, West Bengal, India
⨯
Sujay Ghosh

Roles Conceptualization, Data curation, Funding acquisition, Project administration, Supervision, Writing – original draft

* E-mail: sgzoo@caluniv.ac.in

Affiliation Cytogenetics and Genomics Research Unit, Department of Zoology, University of Calcutta, Taraknath Palit Siksha Prangan (Ballygunge Science College Campus), Kolkata, West Bengal, India

https://orcid.org/0000-0003-1703-8446

⨯

The etiology of Down syndrome: Maternal MCM9 polymorphisms increase risk of reduced recombination and nondisjunction of chromosome 21 during meiosis I within oocyte

Upamanyu Pal,
Pinku Halder,
Anirban Ray,
Sumantra Sarkar,
Supratim Datta,
Papiya Ghosh,
Sujay Ghosh

Published: March 22, 2021
https://doi.org/10.1371/journal.pgen.1009462

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