Transcriptomic and epigenomic profiling of young and aged spermatogonial stem cells reveals molecular targets regulating differentiation

Jinyue Liao; Hoi Ching Suen; Alfred Chun Shui Luk; Lele Yang; Annie Wing Tung Lee; Huayu Qi; Tin-Lap Lee

doi:10.1371/journal.pgen.1009369

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Open Access

Peer-reviewed

Research Article

Transcriptomic and epigenomic profiling of young and aged spermatogonial stem cells reveals molecular targets regulating differentiation

Jinyue Liao,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft

Affiliation Developmental and Regenerative Biology Program, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China

https://orcid.org/0000-0003-3392-3760

⨯
Hoi Ching Suen,

Roles Data curation, Formal analysis, Investigation, Validation, Visualization, Writing – review & editing

Affiliation Developmental and Regenerative Biology Program, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China

https://orcid.org/0000-0003-4060-8603

⨯
Alfred Chun Shui Luk,

Roles Investigation, Validation, Writing – review & editing

Affiliation Developmental and Regenerative Biology Program, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
⨯
Lele Yang,

Roles Investigation, Validation, Writing – review & editing

Affiliation Guangzhou Regenerative Medicine and Health Bioland Laboratory, Guangzhou Institutes of Biomedicine and Health, Guangzhou, China
⨯
Annie Wing Tung Lee,

Roles Writing – review & editing

Affiliation Developmental and Regenerative Biology Program, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
⨯
Huayu Qi,

Roles Investigation, Writing – review & editing

Affiliation Guangzhou Regenerative Medicine and Health Bioland Laboratory, Guangzhou Institutes of Biomedicine and Health, Guangzhou, China
⨯
Tin-Lap Lee

Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

* E-mail: leetl@cuhk.edu.hk

Affiliation Developmental and Regenerative Biology Program, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China

https://orcid.org/0000-0002-6654-0988

⨯

Transcriptomic and epigenomic profiling of young and aged spermatogonial stem cells reveals molecular targets regulating differentiation

Jinyue Liao,
Hoi Ching Suen,
Alfred Chun Shui Luk,
Lele Yang,
Annie Wing Tung Lee,
Huayu Qi,
Tin-Lap Lee

Published: July 8, 2021
https://doi.org/10.1371/journal.pgen.1009369

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Gene expression
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Spermatogonia
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Cell differentiation
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Long non-coding RNA
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Gene regulation
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DNA methylation
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Stem cells
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Epigenetics
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