Probing the aggregated effects of purifying selection per individual on 1,380 medical phenotypes in the UK Biobank

Ha My T. Vy; Daniel M. Jordan; Daniel J. Balick; Ron Do

doi:10.1371/journal.pgen.1009337

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Peer-reviewed

Research Article

Probing the aggregated effects of purifying selection per individual on 1,380 medical phenotypes in the UK Biobank

Ha My T. Vy ,

Contributed equally to this work with: Ha My T. Vy, Daniel M. Jordan, Daniel J. Balick

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

Affiliations The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America, Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America

https://orcid.org/0000-0002-5117-3740

⨯
Daniel M. Jordan ,

Contributed equally to this work with: Ha My T. Vy, Daniel M. Jordan, Daniel J. Balick

Roles Investigation, Writing – original draft, Writing – review & editing

Affiliations The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America, Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America

https://orcid.org/0000-0002-5318-8225

⨯
Daniel J. Balick ,

Contributed equally to this work with: Ha My T. Vy, Daniel M. Jordan, Daniel J. Balick

Roles Investigation, Writing – original draft, Writing – review & editing

Affiliations Division of Genetics, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Biomedical Informatics, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Ron Do

Roles Conceptualization, Funding acquisition, Investigation, Methodology, Supervision, Writing – original draft, Writing – review & editing

* E-mail: ron.do@mssm.edu

Affiliations The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America, Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America

https://orcid.org/0000-0002-3144-3627

⨯

Probing the aggregated effects of purifying selection per individual on 1,380 medical phenotypes in the UK Biobank

Ha My T. Vy,
Daniel M. Jordan,
Daniel J. Balick,
Ron Do

Published: January 25, 2021
https://doi.org/10.1371/journal.pgen.1009337

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