Pleiotropy and epistasis within and between signaling pathways defines the genetic architecture of fungal virulence

Cullen Roth; Debra Murray; Alexandria Scott; Ci Fu; Anna F. Averette; Sheng Sun; Joseph Heitman; Paul M. Magwene

doi:10.1371/journal.pgen.1009313

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Open Access

Peer-reviewed

Research Article

Pleiotropy and epistasis within and between signaling pathways defines the genetic architecture of fungal virulence

Cullen Roth,

Roles Data curation, Formal analysis, Investigation, Methodology, Software, Visualization, Writing – original draft, Writing – review & editing

Affiliations Department of Biology, Duke University, Durham, North Carolina, United States of America, University Program in Genetics and Genomics, Duke University, Durham, North Carolina, United States of America

https://orcid.org/0000-0003-4934-6160

⨯
Debra Murray,

Roles Investigation, Writing – review & editing

Affiliation Department of Biology, Duke University, Durham, North Carolina, United States of America
⨯
Alexandria Scott,

Roles Investigation

Affiliation Department of Biology, Duke University, Durham, North Carolina, United States of America

https://orcid.org/0000-0001-5568-7565

⨯
Ci Fu,

Roles Investigation, Writing – review & editing

Affiliation Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, United States of America
⨯
Anna F. Averette,

Roles Investigation

Affiliation Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, United States of America
⨯
Sheng Sun,

Roles Investigation, Writing – review & editing

Affiliation Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, United States of America

https://orcid.org/0000-0002-2895-1153

⨯
Joseph Heitman,

Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Writing – review & editing

Affiliation Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, United States of America
⨯
Paul M. Magwene

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

* E-mail: paul.magwene@duke.edu

Affiliation Department of Biology, Duke University, Durham, North Carolina, United States of America

https://orcid.org/0000-0002-7659-2589

⨯

Pleiotropy and epistasis within and between signaling pathways defines the genetic architecture of fungal virulence

Cullen Roth,
Debra Murray,
Alexandria Scott,
Ci Fu,
Anna F. Averette,
Sheng Sun,
Joseph Heitman,
Paul M. Magwene

Published: January 25, 2021
https://doi.org/10.1371/journal.pgen.1009313

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Amphotericin
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Cryptococcus
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