UV-exposure, endogenous DNA damage, and DNA replication errors shape the spectra of genome changes in human skin

• Natalie Saini,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  Current address: Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina, United States of America

  Affiliation Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, US National Institutes of Health, Research Triangle Park, North Carolina, United States of America

  https://orcid.org/0000-0002-1668-5417

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• Camille K. Giacobone,

  Roles Formal analysis, Investigation

  Affiliation Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, US National Institutes of Health, Research Triangle Park, North Carolina, United States of America

  https://orcid.org/0000-0003-2937-560X

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• Leszek J. Klimczak,

  Roles Data curation, Formal analysis, Software

  Affiliation Integrative Bioinformatics Support Group, National Institute of Environmental Health Sciences, US National Institutes of Health, Research Triangle Park, North Carolina, United States of America

  https://orcid.org/0000-0003-3048-2576

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• Brian N. Papas,

  Roles Data curation

  Affiliation Integrative Bioinformatics Support Group, National Institute of Environmental Health Sciences, US National Institutes of Health, Research Triangle Park, North Carolina, United States of America

  https://orcid.org/0000-0003-4540-1142

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• Adam B. Burkholder,

  Roles Data curation

  Affiliation Integrative Bioinformatics Support Group, National Institute of Environmental Health Sciences, US National Institutes of Health, Research Triangle Park, North Carolina, United States of America

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• Jian-Liang Li,

  Roles Data curation, Project administration

  Affiliation Integrative Bioinformatics Support Group, National Institute of Environmental Health Sciences, US National Institutes of Health, Research Triangle Park, North Carolina, United States of America

  https://orcid.org/0000-0002-6487-081X

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• David C. Fargo,

  Roles Data curation, Project administration, Resources

  Affiliation Integrative Bioinformatics Support Group, National Institute of Environmental Health Sciences, US National Institutes of Health, Research Triangle Park, North Carolina, United States of America

  https://orcid.org/0000-0003-4728-2642

  ⨯
• Re Bai,

  Roles Investigation, Validation

  Affiliation Molecular Genomics Core Laboratory, National Institute of Environmental Health Sciences, US National Institutes of Health, Research Triangle Park, North Carolina, United States of America

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• Kevin Gerrish,

  Roles Investigation, Resources, Validation, Writing – review & editing

  Affiliation Molecular Genomics Core Laboratory, National Institute of Environmental Health Sciences, US National Institutes of Health, Research Triangle Park, North Carolina, United States of America

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• Cynthia L. Innes,

  Roles Investigation, Validation

  Affiliation Clinical Research Unit, National Institute of Environmental Health Sciences, US National Institutes of Health, Research Triangle Park, North Carolina, United States of America

  https://orcid.org/0000-0002-2273-2662

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• Shepherd H. Schurman,

  Roles Investigation, Methodology, Project administration, Validation, Writing – review & editing

  Affiliation Clinical Research Unit, National Institute of Environmental Health Sciences, US National Institutes of Health, Research Triangle Park, North Carolina, United States of America

  https://orcid.org/0000-0002-9133-7906

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• Dmitry A. Gordenin

  Roles Conceptualization, Formal analysis, Funding acquisition, Methodology, Project administration, Resources, Supervision, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: gordenin@niehs.nih.gov

  Affiliation Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, US National Institutes of Health, Research Triangle Park, North Carolina, United States of America

  https://orcid.org/0000-0002-8399-1836

  ⨯