Genetic diversity of the Plasmodium falciparum GTP-cyclohydrolase 1, dihydrofolate reductase and dihydropteroate synthetase genes reveals new insights into sulfadoxine-pyrimethamine antimalarial drug resistance

Anna Turkiewicz; Emilia Manko; Colin J. Sutherland; Ernest Diez Benavente; Susana Campino; Taane G. Clark

doi:10.1371/journal.pgen.1009268

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Peer-reviewed

Research Article

Genetic diversity of the Plasmodium falciparum GTP-cyclohydrolase 1, dihydrofolate reductase and dihydropteroate synthetase genes reveals new insights into sulfadoxine-pyrimethamine antimalarial drug resistance

Anna Turkiewicz,

Roles Data curation, Formal analysis, Software, Writing – original draft, Writing – review & editing

Affiliation Department of Infection Biology, London School of Hygiene and Tropical Medicine, London, United Kingdom

https://orcid.org/0000-0002-7829-1683

⨯
Emilia Manko,

Roles Data curation, Methodology, Resources, Software

Affiliation Department of Infection Biology, London School of Hygiene and Tropical Medicine, London, United Kingdom

https://orcid.org/0000-0001-7405-6523

⨯
Colin J. Sutherland,

Roles Resources, Writing – review & editing

Affiliation Department of Infection Biology, London School of Hygiene and Tropical Medicine, London, United Kingdom

https://orcid.org/0000-0003-1592-6407

⨯
Ernest Diez Benavente,

Roles Data curation, Resources, Supervision

Affiliation Department of Infection Biology, London School of Hygiene and Tropical Medicine, London, United Kingdom

https://orcid.org/0000-0002-4313-4290

⨯
Susana Campino,

Roles Conceptualization, Investigation, Project administration, Supervision, Writing – review & editing

Affiliation Department of Infection Biology, London School of Hygiene and Tropical Medicine, London, United Kingdom

https://orcid.org/0000-0003-1403-6138

⨯
Taane G. Clark

Roles Conceptualization, Funding acquisition, Investigation, Supervision, Writing – original draft, Writing – review & editing

* E-mail: taane.clark@lshtm.ac.uk

Current address: Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom

Affiliations Department of Infection Biology, London School of Hygiene and Tropical Medicine, London, United Kingdom, Department of Infectious Disease Epidemiology, Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom

https://orcid.org/0000-0001-8985-9265

⨯

Genetic diversity of the Plasmodium falciparum GTP-cyclohydrolase 1, dihydrofolate reductase and dihydropteroate synthetase genes reveals new insights into sulfadoxine-pyrimethamine antimalarial drug resistance

Anna Turkiewicz,
Emilia Manko,
Colin J. Sutherland,
Ernest Diez Benavente,
Susana Campino,
Taane G. Clark

Published: December 31, 2020
https://doi.org/10.1371/journal.pgen.1009268

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