TDP-43 mutations link Amyotrophic Lateral Sclerosis with R-loop homeostasis and R loop-mediated DNA damage

• Marta Giannini ,

  Contributed equally to this work with: Marta Giannini, Aleix Bayona-Feliu, Daisy Sproviero

  Roles Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliations Genomic and Post-Genomic Center, IRCCS Mondino Foundation, Pavia, Italy, Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy, Andalusian Center of Molecular Biology and Regenerative Medicine-CABIMER, Universidad de Sevilla-CSIC-Universidad Pablo de Olavide, Seville, Spain

  https://orcid.org/0000-0002-8942-2749

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• Aleix Bayona-Feliu ,

  Contributed equally to this work with: Marta Giannini, Aleix Bayona-Feliu, Daisy Sproviero

  Roles Formal analysis, Methodology, Resources, Supervision, Visualization, Writing – review & editing

  Affiliations Andalusian Center of Molecular Biology and Regenerative Medicine-CABIMER, Universidad de Sevilla-CSIC-Universidad Pablo de Olavide, Seville, Spain, Departamento de Genética, Facultad de Biología, Universidad de Sevilla, Seville, Spain

  https://orcid.org/0000-0002-7412-1652

  ⨯
• Daisy Sproviero ,

  Contributed equally to this work with: Marta Giannini, Aleix Bayona-Feliu, Daisy Sproviero

  Roles Formal analysis, Investigation, Methodology, Supervision, Visualization, Writing – review & editing

  Affiliation Genomic and Post-Genomic Center, IRCCS Mondino Foundation, Pavia, Italy

  https://orcid.org/0000-0001-5061-683X

  ⨯
• Sonia I. Barroso,

  Roles Investigation

  Affiliation Andalusian Center of Molecular Biology and Regenerative Medicine-CABIMER, Universidad de Sevilla-CSIC-Universidad Pablo de Olavide, Seville, Spain

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• Cristina Cereda ,

  Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: cristina.cereda@mondino.it (CC); aguilo@us.es (AA)

  Affiliation Genomic and Post-Genomic Center, IRCCS Mondino Foundation, Pavia, Italy

  https://orcid.org/0000-0001-9571-0862

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• Andrés Aguilera

  Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: cristina.cereda@mondino.it (CC); aguilo@us.es (AA)

  Affiliations Andalusian Center of Molecular Biology and Regenerative Medicine-CABIMER, Universidad de Sevilla-CSIC-Universidad Pablo de Olavide, Seville, Spain, Departamento de Genética, Facultad de Biología, Universidad de Sevilla, Seville, Spain

  https://orcid.org/0000-0003-4782-1714

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