ARID1A regulates R-loop associated DNA replication stress

Shuhe Tsai; Louis-Alexandre Fournier; Emily Yun-chia Chang; James P. Wells; Sean W. Minaker; Yi Dan Zhu; Alan Ying-Hsu Wang; Yemin Wang; David G. Huntsman; Peter C. Stirling

doi:10.1371/journal.pgen.1009238

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Open Access

Peer-reviewed

Research Article

ARID1A regulates R-loop associated DNA replication stress

Shuhe Tsai,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Terry Fox Laboratory, BC Cancer, Vancouver, Canada
⨯
Louis-Alexandre Fournier,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Visualization

Affiliation Terry Fox Laboratory, BC Cancer, Vancouver, Canada

https://orcid.org/0000-0002-4649-1197

⨯
Emily Yun-chia Chang,

Roles Formal analysis, Investigation, Methodology

Affiliation Terry Fox Laboratory, BC Cancer, Vancouver, Canada
⨯
James P. Wells,

Roles Formal analysis, Investigation

Affiliation Terry Fox Laboratory, BC Cancer, Vancouver, Canada

https://orcid.org/0000-0002-3231-1810

⨯
Sean W. Minaker,

Roles Formal analysis, Investigation

Affiliation Terry Fox Laboratory, BC Cancer, Vancouver, Canada
⨯
Yi Dan Zhu,

Roles Formal analysis, Investigation

Affiliation Terry Fox Laboratory, BC Cancer, Vancouver, Canada

https://orcid.org/0000-0001-6327-8673

⨯
Alan Ying-Hsu Wang,

Roles Formal analysis, Investigation

Affiliation Terry Fox Laboratory, BC Cancer, Vancouver, Canada

https://orcid.org/0000-0003-1304-6000

⨯
Yemin Wang,

Roles Resources

Affiliation Department of Molecular Oncology, BC Cancer, Vancouver, Canada

https://orcid.org/0000-0002-2970-9510

⨯
David G. Huntsman,

Roles Project administration, Resources

Affiliation Department of Molecular Oncology, BC Cancer, Vancouver, Canada
⨯
Peter C. Stirling

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: pstirling@bccrc.ca

Affiliations Terry Fox Laboratory, BC Cancer, Vancouver, Canada, Department of Medical Genetics, University of British Columbia, Vancouver, Canada

https://orcid.org/0000-0003-2651-4539

⨯

ARID1A regulates R-loop associated DNA replication stress

Shuhe Tsai,
Louis-Alexandre Fournier,
Emily Yun-chia Chang,
James P. Wells,
Sean W. Minaker,
Yi Dan Zhu,
Alan Ying-Hsu Wang,
Yemin Wang,
David G. Huntsman,
Peter C. Stirling

Published: April 7, 2021
https://doi.org/10.1371/journal.pgen.1009238

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DNA replication
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Chromatin
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Cell staining
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Small interfering RNA
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DNA damage
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Immunoprecipitation
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