Dual genome-wide CRISPR knockout and CRISPR activation screens identify mechanisms that regulate the resistance to multiple ATR inhibitors

Emily M. Schleicher; Ashna Dhoonmoon; Lindsey M. Jackson; Kristen E. Clements; Coryn L. Stump; Claudia M. Nicolae; George-Lucian Moldovan

doi:10.1371/journal.pgen.1009176

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Open Access

Peer-reviewed

Research Article

Dual genome-wide CRISPR knockout and CRISPR activation screens identify mechanisms that regulate the resistance to multiple ATR inhibitors

Emily M. Schleicher,

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Methodology, Validation, Writing – original draft, Writing – review & editing

Affiliation Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, United States of America

https://orcid.org/0000-0002-2315-346X

⨯
Ashna Dhoonmoon,

Roles Data curation, Formal analysis

Affiliation Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, United States of America

https://orcid.org/0000-0001-9661-4477

⨯
Lindsey M. Jackson,

Roles Data curation, Formal analysis

Affiliation Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, United States of America

https://orcid.org/0000-0002-0559-9433

⨯
Kristen E. Clements,

Roles Data curation, Formal analysis, Methodology

Affiliation Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, United States of America

https://orcid.org/0000-0002-6877-3507

⨯
Coryn L. Stump,

Roles Data curation, Formal analysis

Affiliation Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, United States of America

https://orcid.org/0000-0003-4218-1260

⨯
Claudia M. Nicolae,

Roles Data curation, Formal analysis, Validation

Affiliation Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, United States of America

https://orcid.org/0000-0003-4933-5496

⨯
George-Lucian Moldovan

Roles Conceptualization, Funding acquisition, Supervision, Writing – original draft, Writing – review & editing

* E-mail: glm29@psu.edu

Affiliation Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, United States of America

https://orcid.org/0000-0003-3825-149X

⨯

Dual genome-wide CRISPR knockout and CRISPR activation screens identify mechanisms that regulate the resistance to multiple ATR inhibitors

Emily M. Schleicher,
Ashna Dhoonmoon,
Lindsey M. Jackson,
Kristen E. Clements,
Coryn L. Stump,
Claudia M. Nicolae,
George-Lucian Moldovan

Published: November 2, 2020
https://doi.org/10.1371/journal.pgen.1009176

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