Modeling epistasis in mice and yeast using the proportion of two or more distinct genetic backgrounds: Evidence for “polygenic epistasis”

• Christoph D. Rau,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Resources, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America

  https://orcid.org/0000-0002-0782-207X

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• Natalia M. Gonzales,

  Roles Data curation, Investigation, Resources, Writing – review & editing

  Affiliation Department of Human Genetics, University of Chicago, Chicago, IL, United States of America

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• Joshua S. Bloom,

  Roles Data curation, Investigation, Resources, Writing – review & editing

  Affiliation Department of Human Genetics, UCLA, Los Angeles, CA, United States of America

  https://orcid.org/0000-0002-7241-1648

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• Danny Park,

  Roles Conceptualization, Methodology, Writing – review & editing

  Affiliation Department of Medicine, UCSF, San Francisco, CA, United States of America

  https://orcid.org/0000-0001-7302-9929

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• Julien Ayroles,

  Roles Methodology, Writing – review & editing

  Affiliation Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ, United States of America

  https://orcid.org/0000-0001-8729-0511

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• Abraham A. Palmer,

  Roles Resources, Writing – review & editing

  Affiliation Department of Psychiatry, and Institute for Genomic Medicine, UCSD, San Diego, CA, United States of America

  https://orcid.org/0000-0003-3634-0747

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• Aldons J. Lusis,

  Roles Resources, Writing – review & editing

  Affiliation Department of Human Genetics, UCLA, Los Angeles, CA, United States of America

  https://orcid.org/0000-0001-9013-0228

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• Noah Zaitlen

  Roles Conceptualization, Funding acquisition, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: nzaitlen@mednet.ucla.edu

  Affiliation Department of Neurology, UCLA, Los Angeles, CA, United States of America

  https://orcid.org/0000-0002-3553-3670

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