Hypomethylation of GDNF family receptor alpha 1 promotes epithelial-mesenchymal transition and predicts metastasis of colorectal cancer

Zhexu Dong; Lei Dai; Yong Zhang; Chao Fang; Gang Shi; Ye Chen; Junshu Li; Qin Wang; Jiamei Fu; Yan Yu; Wenshuang Wang; Lin Cheng; Yi Liu; Yi Lin; Yuan Wang; Qingnan Wang; Huiling Wang; Hantao Zhang; Yujing Zhang; Xiaolan Su; Shuang Zhang; Feng Wang; Meng Qiu; Zongguang Zhou; Hongxin Deng

doi:10.1371/journal.pgen.1009159

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Open Access

Peer-reviewed

Research Article

Hypomethylation of GDNF family receptor alpha 1 promotes epithelial-mesenchymal transition and predicts metastasis of colorectal cancer

Zhexu Dong ,

Contributed equally to this work with: Zhexu Dong, Lei Dai

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan, the People’s Republic of China
⨯
Lei Dai ,

Contributed equally to this work with: Zhexu Dong, Lei Dai

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Resources, Writing – review & editing

Affiliation State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan, the People’s Republic of China
⨯
Yong Zhang,

Roles Data curation, Formal analysis, Investigation, Resources, Software, Visualization, Writing – review & editing

Affiliation State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan, the People’s Republic of China
⨯
Chao Fang,

Roles Resources

Affiliation Department of Gastrointestinal Surgery, West China Hospital and State Key Laboratory of Biotherapy, Sichuan University, Chengdu, Sichuan, the People’s Republic of China
⨯
Gang Shi,

Roles Data curation, Methodology, Supervision, Writing – review & editing

Affiliation State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan, the People’s Republic of China
⨯
Ye Chen,

Roles Resources

Affiliation Department of Medical Oncology, Cancer Center, the State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan, the People’s Republic of China
⨯
Junshu Li,

Roles Validation

Affiliation State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan, the People’s Republic of China
⨯
Qin Wang,

Roles Methodology

Affiliation State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan, the People’s Republic of China
⨯
Jiamei Fu,

Roles Validation

Affiliation State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan, the People’s Republic of China
⨯
Yan Yu,

Roles Validation

Affiliation State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan, the People’s Republic of China
⨯
Wenshuang Wang,

Roles Validation

Affiliation State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan, the People’s Republic of China
⨯
Lin Cheng,

Roles Supervision

Affiliation State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan, the People’s Republic of China
⨯
Yi Liu,

Roles Methodology

Affiliation State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan, the People’s Republic of China
⨯
Yi Lin,

Roles Methodology

Affiliation State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan, the People’s Republic of China
⨯
Yuan Wang,

Roles Methodology

Affiliation State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan, the People’s Republic of China
⨯
Qingnan Wang,

Roles Methodology

Affiliation State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan, the People’s Republic of China
⨯
Huiling Wang,

Roles Methodology

Affiliation State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan, the People’s Republic of China
⨯
Hantao Zhang,

Roles Methodology

Affiliation State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan, the People’s Republic of China
⨯
Yujing Zhang,

Roles Methodology

Affiliation State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan, the People’s Republic of China
⨯
Xiaolan Su,

Roles Methodology

Affiliation State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan, the People’s Republic of China
⨯
Shuang Zhang,

Roles Supervision

Affiliation Department of biotherapy, Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan, the People’s Republic of China
⨯
Feng Wang,

Roles Resources

Affiliations Department of Medical Oncology, Cancer Center, the State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan, the People’s Republic of China, Department of Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, the People’s Republic of China
⨯
Meng Qiu,

Roles Resources

Affiliation Department of Medical Oncology, Cancer Center, the State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan, the People’s Republic of China
⨯
Zongguang Zhou,

Roles Resources

Affiliation Department of Gastrointestinal Surgery, West China Hospital and State Key Laboratory of Biotherapy, Sichuan University, Chengdu, Sichuan, the People’s Republic of China
⨯
[ ... ],
Hongxin Deng

Roles Conceptualization, Data curation, Funding acquisition, Methodology, Writing – review & editing

* E-mail: denghongx@scu.edu.cn

Affiliation State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan, the People’s Republic of China

https://orcid.org/0000-0001-5094-1376

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Hypomethylation of GDNF family receptor alpha 1 promotes epithelial-mesenchymal transition and predicts metastasis of colorectal cancer

Zhexu Dong,
Lei Dai,
Yong Zhang,
Chao Fang,
Gang Shi,
Ye Chen,
Junshu Li,
Qin Wang,
Jiamei Fu,
Yan Yu

Published: November 11, 2020
https://doi.org/10.1371/journal.pgen.1009159

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DNA methylation
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