Inhibition of the de novo pyrimidine biosynthesis pathway limits ribosomal RNA transcription causing nucleolar stress in glioblastoma cells

• M. Carmen Lafita-Navarro,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

  https://orcid.org/0000-0002-7266-651X

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• Niranjan Venkateswaran,

  Roles Investigation, Methodology

  Affiliation Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

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• Jessica A. Kilgore,

  Roles Investigation, Methodology

  Affiliation Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

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• Suman Kanji,

  Roles Investigation, Methodology

  Affiliation Department of Neurosurgery, University of Texas Health Science Center, San Antonio, Texas, United States of America

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• Jungsoo Han,

  Roles Investigation, Methodology

  Affiliation Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

  https://orcid.org/0000-0002-5066-0555

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• Spencer Barnes,

  Roles Investigation, Methodology

  Affiliation Bioinformatics Core Facility, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

  https://orcid.org/0000-0003-1103-0953

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• Noelle S. Williams,

  Roles Investigation, Methodology

  Affiliation Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

  https://orcid.org/0000-0003-1894-5742

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• Michael Buszczak,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliation Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

  https://orcid.org/0000-0001-6361-3654

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• Sandeep Burma,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliations Department of Neurosurgery, University of Texas Health Science Center, San Antonio, Texas, United States of America, Department of Biochemistry and Structural Biology, University of Texas Health Science Center, San Antonio, Texas, United States of America

  https://orcid.org/0000-0001-7057-9845

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• Maralice Conacci-Sorrell

  Roles Conceptualization, Funding acquisition, Investigation, Project administration, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: Maralice.ConacciSorrell@UTSouthwestern.edu

  Affiliations Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America, Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX, United States of America, Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

  https://orcid.org/0000-0002-4371-5087

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