Mesenchyme-derived IGF2 is a major paracrine regulator of pancreatic growth and function

Constanze M. Hammerle; Ionel Sandovici; Gemma V. Brierley; Nicola M. Smith; Warren E. Zimmer; Ilona Zvetkova; Haydn M. Prosser; Yoichi Sekita; Brian Y. H. Lam; Marcella Ma; Wendy N. Cooper; Antonio Vidal-Puig; Susan E. Ozanne; Gema Medina-Gómez; Miguel Constância

doi:10.1371/journal.pgen.1009069

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Open Access

Peer-reviewed

Research Article

Mesenchyme-derived IGF2 is a major paracrine regulator of pancreatic growth and function

Constanze M. Hammerle ,

Contributed equally to this work with: Constanze M. Hammerle, Ionel Sandovici

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

Current address: Novo Nordisk A/S, Bagsværd, Denmark

Affiliations University of Cambridge Metabolic Research Laboratories and MRC Metabolic Diseases Unit, Institute of Metabolic Science, Addenbrookes Hospital, Cambridge, United Kingdom, Department of Obstetrics and Gynaecology and National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge, United Kingdom

https://orcid.org/0000-0001-6563-7342

⨯
Ionel Sandovici ,

Contributed equally to this work with: Constanze M. Hammerle, Ionel Sandovici

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliations University of Cambridge Metabolic Research Laboratories and MRC Metabolic Diseases Unit, Institute of Metabolic Science, Addenbrookes Hospital, Cambridge, United Kingdom, Department of Obstetrics and Gynaecology and National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge, United Kingdom, Centre for Trophoblast Research, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, United Kingdom

https://orcid.org/0000-0001-5674-4269

⨯
Gemma V. Brierley,

Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – review & editing

Affiliation University of Cambridge Metabolic Research Laboratories and MRC Metabolic Diseases Unit, Institute of Metabolic Science, Addenbrookes Hospital, Cambridge, United Kingdom

https://orcid.org/0000-0002-4600-9970

⨯
Nicola M. Smith,

Roles Data curation, Formal analysis, Investigation, Methodology

Affiliations University of Cambridge Metabolic Research Laboratories and MRC Metabolic Diseases Unit, Institute of Metabolic Science, Addenbrookes Hospital, Cambridge, United Kingdom, Department of Obstetrics and Gynaecology and National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge, United Kingdom

https://orcid.org/0000-0002-5137-1384

⨯
Warren E. Zimmer,

Roles Resources

Affiliation Department of Medical Physiology, Texas A&M Health Science Center, College Station, Texas, United States of America
⨯
Ilona Zvetkova,

Roles Methodology, Resources

Affiliation University of Cambridge Metabolic Research Laboratories and MRC Metabolic Diseases Unit, Institute of Metabolic Science, Addenbrookes Hospital, Cambridge, United Kingdom

https://orcid.org/0000-0003-4356-0086

⨯
Haydn M. Prosser,

Roles Methodology, Resources

Current address: Cambridge Institute of Therapeutic Immunology & Infectious Disease. Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, University of Cambridge, United Kingdom

Affiliation The Wellcome Trust Sanger Institute, Genome Campus, Hinxton, United Kingdom

https://orcid.org/0000-0002-9897-2152

⨯
Yoichi Sekita,

Roles Investigation, Methodology, Resources

Current address: Laboratory of Stem Cell Biology, Department of Biosciences, Kitasato University School of Science, Kanagawa, Japan

Affiliation University of Cambridge Metabolic Research Laboratories and MRC Metabolic Diseases Unit, Institute of Metabolic Science, Addenbrookes Hospital, Cambridge, United Kingdom

https://orcid.org/0000-0002-6230-8719

⨯
Brian Y. H. Lam,

Roles Data curation, Formal analysis, Investigation, Software, Writing – review & editing

Affiliation University of Cambridge Metabolic Research Laboratories and MRC Metabolic Diseases Unit, Institute of Metabolic Science, Addenbrookes Hospital, Cambridge, United Kingdom
⨯
Marcella Ma,

Roles Methodology

Affiliation University of Cambridge Metabolic Research Laboratories and MRC Metabolic Diseases Unit, Institute of Metabolic Science, Addenbrookes Hospital, Cambridge, United Kingdom
⨯
Wendy N. Cooper,

Roles Data curation, Formal analysis, Investigation, Software

Affiliations University of Cambridge Metabolic Research Laboratories and MRC Metabolic Diseases Unit, Institute of Metabolic Science, Addenbrookes Hospital, Cambridge, United Kingdom, Department of Obstetrics and Gynaecology and National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge, United Kingdom

https://orcid.org/0000-0003-3416-9982

⨯
Antonio Vidal-Puig,

Roles Conceptualization, Funding acquisition

Affiliation University of Cambridge Metabolic Research Laboratories and MRC Metabolic Diseases Unit, Institute of Metabolic Science, Addenbrookes Hospital, Cambridge, United Kingdom

https://orcid.org/0000-0003-4220-9577

⨯
Susan E. Ozanne,

Roles Conceptualization, Funding acquisition, Writing – review & editing

Affiliation University of Cambridge Metabolic Research Laboratories and MRC Metabolic Diseases Unit, Institute of Metabolic Science, Addenbrookes Hospital, Cambridge, United Kingdom

https://orcid.org/0000-0001-8753-5144

⨯
Gema Medina-Gómez,

Roles Conceptualization, Data curation, Investigation, Writing – review & editing

Affiliation Área de Bioquímica y Biología Molecular, Departamento de Ciencias Básicas de la Salud, Universidad Rey Juan Carlos, 28922-Alcorcón, Madrid, Spain

https://orcid.org/0000-0001-8169-681X

⨯
Miguel Constância

Roles Conceptualization, Data curation, Funding acquisition, Project administration, Supervision, Validation, Writing – original draft, Writing – review & editing

* E-mail: jmasmc2@cam.ac.uk

Affiliations University of Cambridge Metabolic Research Laboratories and MRC Metabolic Diseases Unit, Institute of Metabolic Science, Addenbrookes Hospital, Cambridge, United Kingdom, Department of Obstetrics and Gynaecology and National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge, United Kingdom, Centre for Trophoblast Research, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, United Kingdom

https://orcid.org/0000-0002-8976-1679

⨯

Mesenchyme-derived IGF2 is a major paracrine regulator of pancreatic growth and function

Constanze M. Hammerle,
Ionel Sandovici,
Gemma V. Brierley,
Nicola M. Smith,
Warren E. Zimmer,
Ilona Zvetkova,
Haydn M. Prosser,
Yoichi Sekita,
Brian Y. H. Lam,
Marcella Ma

Published: October 15, 2020
https://doi.org/10.1371/journal.pgen.1009069

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