The causal effect of obesity on prediabetes and insulin resistance reveals the important role of adipose tissue in insulin resistance

• Zong Miao,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America, Bioinformatics Interdepartmental Program, UCLA, Los Angeles, California, United States of America

  http://orcid.org/0000-0002-6183-4565

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• Marcus Alvarez,

  Roles Data curation, Methodology, Software, Writing – review & editing

  Affiliation Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America

  http://orcid.org/0000-0002-6369-5028

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• Arthur Ko,

  Roles Data curation, Writing – review & editing

  Affiliation Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America

  http://orcid.org/0000-0002-1523-7225

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• Yash Bhagat,

  Roles Data curation, Writing – review & editing

  Affiliation Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America

  http://orcid.org/0000-0002-3437-1817

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• Elior Rahmani,

  Roles Methodology, Writing – review & editing

  Affiliation Computer Science Department in the School of Engineering, UCLA, Los Angeles, California, United States of America

  http://orcid.org/0000-0002-9017-2070

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• Brandon Jew,

  Roles Methodology, Writing – review & editing

  Affiliations Bioinformatics Interdepartmental Program, UCLA, Los Angeles, California, United States of America, Computer Science Department in the School of Engineering, UCLA, Los Angeles, California, United States of America

  http://orcid.org/0000-0002-1848-1880

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• Sini Heinonen,

  Roles Data curation, Writing – review & editing

  Affiliation Obesity Research Unit, Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland

  http://orcid.org/0000-0002-6342-0577

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• Linda Liliana Muñoz-Hernandez,

  Roles Data curation, Writing – review & editing

  Affiliations Unidad de Investigación en Enfermedades Metabólicas, Dirección de Nutrición, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, Departamento de Endocrinología y Metabolismo, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Monterrey, Nuevo Leon, México

  ⨯
• Miguel Herrera-Hernandez,

  Roles Data curation, Writing – review & editing

  Affiliation Departamento de Cirugía, Instituto Nacional de Ciencias Médicas y Nutrición, Mexico City, Mexico

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• Carlos Aguilar-Salinas,

  Roles Data curation, Writing – review & editing

  Affiliations Unidad de Investigación en Enfermedades Metabólicas, Dirección de Nutrición, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, Departamento de Endocrinología y Metabolismo, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Monterrey, Nuevo Leon, México

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• Teresa Tusie-Luna,

  Roles Data curation, Writing – review & editing

  Affiliation Unidad de Biología Molecular y Medicina Genómica Instituto de Investigaciones Biomédicas UNAM / Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubiran, Mexico City, Mexico

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• Karen L. Mohlke,

  Roles Data curation, Writing – review & editing

  Affiliation Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, United States of America

  http://orcid.org/0000-0001-6721-153X

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• Markku Laakso,

  Roles Data curation, Writing – review & editing

  Affiliation Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland

  http://orcid.org/0000-0002-3394-7749

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• Kirsi H. Pietiläinen,

  Roles Data curation, Writing – review & editing

  Affiliations Obesity Research Unit, Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland, Obesity Center, Endocrinology, Abdominal Center, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland

  http://orcid.org/0000-0002-8522-1288

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• Eran Halperin,

  Roles Methodology, Writing – review & editing

  Affiliations Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America, Computer Science Department in the School of Engineering, UCLA, Los Angeles, California, United States of America, Department of Computational Medicine, UCLA, Los Angeles, California, United States of America, Department of Anesthesiology and Perioperative Medicine, UCLA, Los Angeles, California, United States of America, Institute for Precision Health, David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America

  http://orcid.org/0000-0002-2373-3691

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•  [ ... ],
• Päivi Pajukanta

  Roles Conceptualization, Data curation, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Writing – original draft, Writing – review & editing

  * E-mail: ppajukanta@mednet.ucla.edu

  Affiliations Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America, Bioinformatics Interdepartmental Program, UCLA, Los Angeles, California, United States of America, Institute for Precision Health, David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America

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