Predominance of positive epistasis among drug resistance-associated mutations in HIV-1 protease

• Tian-hao Zhang ,

  Contributed equally to this work with: Tian-hao Zhang, Lei Dai

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Molecular Biology Institute, University of California, Los Angeles, CA 90095, USA

  https://orcid.org/0000-0002-4422-5581

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• Lei Dai ,

  Contributed equally to this work with: Tian-hao Zhang, Lei Dai

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Software, Supervision, Validation, Writing – original draft, Writing – review & editing

  * E-mail: rensun@hku.hk (RS); lei.dai@siat.ac.cn (LD)

  Affiliation CAS Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China

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• John P. Barton,

  Roles Data curation, Formal analysis, Investigation, Methodology, Software, Writing – original draft, Writing – review & editing

  Affiliation Department of Physics and Astronomy, University of California, Riverside, CA 92521, USA

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• Yushen Du,

  Roles Writing – review & editing

  Affiliations School of Medicine, ZheJiang University, Hangzhou, 210000, China, Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095, USA

  https://orcid.org/0000-0002-8015-4207

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• Yuxiang Tan,

  Roles Writing – review & editing

  Affiliation CAS Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China

  https://orcid.org/0000-0002-1704-1293

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• Wenwen Pang,

  Roles Writing – review & editing

  Affiliation Department of Public Health Laboratory Science, West China School of Public Health, Sichuan University, Chengdu 610041, China

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• Arup K. Chakraborty,

  Roles Writing – review & editing

  Affiliations Institute for Medical Engineering and Science, Departments of Chemical Engineering, Physics, & Chemistry, Massachusetts Institute of Technology, MA 21309, USA, Ragon Institute of MGH, MIT, & Harvard, Cambridge, MA 21309, USA

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• James O. Lloyd-Smith,

  Roles Conceptualization, Investigation, Methodology, Supervision, Writing – review & editing

  Affiliation Department of Ecology and Evolutionary Biology, University of California, Los Angeles, CA 90095, USA

  https://orcid.org/0000-0001-7941-502X

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• Ren Sun

  Roles Funding acquisition, Project administration, Resources, Supervision, Writing – review & editing

  * E-mail: rensun@hku.hk (RS); lei.dai@siat.ac.cn (LD)

  Affiliation Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095, USA

  https://orcid.org/0000-0002-1624-4857

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