Leveraging expression from multiple tissues using sparse canonical correlation analysis and aggregate tests improves the power of transcriptome-wide association studies

• Helian Feng ,

  Roles Formal analysis, Methodology, Visualization, Writing – original draft

  * E-mail: helian@g.harvard.edu

  Affiliations Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America, Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America

  https://orcid.org/0000-0002-6296-1902

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• Nicholas Mancuso,

  Roles Writing – review & editing

  Affiliations Center for Genetic Epidemiology, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America, Division of Biostatistics, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America

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• Alexander Gusev,

  Roles Writing – review & editing

  Affiliations Department of Medical Oncology, Dana-Farber Cancer Institute & Harvard Medical School, Boston, Massachusetts, United States of America, Division of Genetics, Brigham & Women’s Hospital, Boston, MA, United States of America, Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America

  https://orcid.org/0000-0002-7980-4620

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• Arunabha Majumdar,

  Roles Writing – review & editing

  Affiliations Department of Human Genetics, University of California Los Angeles, Los Angeles, California, United States of America, Department of Pathology and Laboratory Medicine, University of California Los Angeles, Los Angeles, California, United States of America

  https://orcid.org/0000-0002-5609-075X

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• Megan Major,

  Roles Writing – review & editing

  Affiliation Bioinformatics Interdepartmental Program, University of California Los Angeles, Los Angeles, California, United States of America

  https://orcid.org/0000-0002-9684-8844

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• Bogdan Pasaniuc,

  Roles Conceptualization, Investigation, Writing – review & editing

  Affiliations Department of Human Genetics, University of California Los Angeles, Los Angeles, California, United States of America, Department of Pathology and Laboratory Medicine, University of California Los Angeles, Los Angeles, California, United States of America

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• Peter Kraft

  Roles Conceptualization, Investigation, Writing – review & editing

  Affiliations Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America, Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America

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