THOC1 deficiency leads to late-onset nonsyndromic hearing loss through p53-mediated hair cell apoptosis

• Luping Zhang ,

  Contributed equally to this work with: Luping Zhang, Yu Gao, Ru Zhang

  Roles Conceptualization, Funding acquisition, Writing – original draft

  Affiliation Department of Otolaryngology-Head and Neck Surgery, Affiliated Hospital, School of Life Science, Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, China

  http://orcid.org/0000-0003-1745-081X

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• Yu Gao ,

  Contributed equally to this work with: Luping Zhang, Yu Gao, Ru Zhang

  Roles Data curation, Formal analysis, Investigation, Writing – original draft

  Affiliation Department of Otolaryngology-Head and Neck Surgery, Affiliated Hospital, School of Life Science, Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, China

  http://orcid.org/0000-0003-2986-8623

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• Ru Zhang ,

  Contributed equally to this work with: Luping Zhang, Yu Gao, Ru Zhang

  Roles Data curation, Formal analysis

  Affiliation Shanghai East Hospital, Department of Otorhinolaryngology Shanghai, Shanghai, China

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• Feifei Sun,

  Roles Data curation, Formal analysis

  Affiliation Department of Otolaryngology-Head and Neck Surgery, Affiliated Hospital, School of Life Science, Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, China

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• Cheng Cheng,

  Roles Formal analysis, Investigation

  Affiliation Key Laboratory for Developmental Genes and Human Disease, Ministry of Education, Institute of Life Sciences, Southeast University, Nanjing, China

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• Fuping Qian,

  Roles Formal analysis, Investigation

  Affiliations Department of Otolaryngology-Head and Neck Surgery, Affiliated Hospital, School of Life Science, Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, China, Key Laboratory for Developmental Genes and Human Disease, Ministry of Education, Institute of Life Sciences, Southeast University, Nanjing, China

  http://orcid.org/0000-0001-5745-9304

  ⨯
• Xuchu Duan,

  Roles Investigation

  Affiliation Department of Otolaryngology-Head and Neck Surgery, Affiliated Hospital, School of Life Science, Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, China

  http://orcid.org/0000-0002-4763-126X

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• Guanyun Wei,

  Roles Investigation

  Affiliation Department of Otolaryngology-Head and Neck Surgery, Affiliated Hospital, School of Life Science, Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, China

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• Cheng Sun,

  Roles Formal analysis, Investigation

  Affiliation Department of Otolaryngology-Head and Neck Surgery, Affiliated Hospital, School of Life Science, Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, China

  http://orcid.org/0000-0001-8411-4619

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• Xiuhong Pang,

  Roles Investigation

  Affiliation Department of Otorhinolaryngology-Head and Neck Surgery, Taizhou People’s Hospital, Fifth Affiliated Hospital, Nantong University, Taizhou, China

  http://orcid.org/0000-0002-1296-5163

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• Penghui Chen,

  Roles Data curation

  Affiliations Department of Otorhinolaryngology-Head and Neck Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China, Ear Institute, Shanghai Jiaotong University School of Medicine, Shanghai, China, Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, China

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• Renjie Chai,

  Roles Supervision

  Affiliations Department of Otolaryngology-Head and Neck Surgery, Affiliated Hospital, School of Life Science, Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, China, Key Laboratory for Developmental Genes and Human Disease, Ministry of Education, Institute of Life Sciences, Southeast University, Nanjing, China

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• Tao Yang ,

  Roles Data curation, Formal analysis, Supervision, Writing – review & editing

  * E-mail: yangtfxl@sina.com (TY); wuhao622@sina.cn (HW); liudongtom@gmail.com, tom@ntu.edu.cn (DL)

  Affiliations Department of Otorhinolaryngology-Head and Neck Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China, Ear Institute, Shanghai Jiaotong University School of Medicine, Shanghai, China, Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, China

  http://orcid.org/0000-0001-6011-987X

  ⨯
• Hao Wu ,

  Roles Supervision, Writing – review & editing

  * E-mail: yangtfxl@sina.com (TY); wuhao622@sina.cn (HW); liudongtom@gmail.com, tom@ntu.edu.cn (DL)

  Affiliations Department of Otorhinolaryngology-Head and Neck Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China, Ear Institute, Shanghai Jiaotong University School of Medicine, Shanghai, China, Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, China

  http://orcid.org/0000-0002-7356-5841

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• Dong Liu

  Roles Conceptualization, Formal analysis, Funding acquisition, Methodology, Writing – original draft, Writing – review & editing

  * E-mail: yangtfxl@sina.com (TY); wuhao622@sina.cn (HW); liudongtom@gmail.com, tom@ntu.edu.cn (DL)

  Affiliation Department of Otolaryngology-Head and Neck Surgery, Affiliated Hospital, School of Life Science, Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, China

  http://orcid.org/0000-0002-2764-6544

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