Linking protein to phenotype with Mendelian Randomization detects 38 proteins with causal roles in human diseases and traits

• Andrew D. Bretherick ,

  Roles Conceptualization, Data curation, Formal analysis, Methodology, Software, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: a.bretherick@ed.ac.uk (ADB); chris.haley@igmm.ed.ac.uk (CH)

  Affiliation MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, United Kingdom

  http://orcid.org/0000-0001-9258-3140

  ⨯
• Oriol Canela-Xandri,

  Roles Data curation, Formal analysis, Software, Writing – review & editing

  Affiliations MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, United Kingdom, The Roslin Institute, University of Edinburgh, Easter Bush, Edinburgh, Scotland, United Kingdom

  http://orcid.org/0000-0003-4601-6289

  ⨯
• Peter K. Joshi,

  Roles Data curation, Software, Writing – review & editing

  Affiliation Centre for Global Health Research, Usher Institute, University of Edinburgh, Teviot Place, Edinburgh, Scotland, United Kingdom

  http://orcid.org/0000-0002-6361-5059

  ⨯
• David W. Clark,

  Roles Software, Writing – review & editing

  Affiliation Centre for Global Health Research, Usher Institute, University of Edinburgh, Teviot Place, Edinburgh, Scotland, United Kingdom

  http://orcid.org/0000-0002-1025-9185

  ⨯
• Konrad Rawlik,

  Roles Data curation, Formal analysis, Software, Writing – review & editing

  Affiliation The Roslin Institute, University of Edinburgh, Easter Bush, Edinburgh, Scotland, United Kingdom

  http://orcid.org/0000-0002-0010-370X

  ⨯
• Thibaud S. Boutin,

  Roles Data curation, Formal analysis, Software, Writing – review & editing

  Affiliation MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, United Kingdom

  http://orcid.org/0000-0003-4754-1675

  ⨯
• Yanni Zeng,

  Roles Writing – review & editing

  Affiliations MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, United Kingdom, Faculty of Forensic Medicine, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China, Guangdong Province Translational Forensic Medicine Engineering Technology Research Center, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China, Guangdong Province Key Laboratory of Brain Function and Disease, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China

  http://orcid.org/0000-0003-3507-5611

  ⨯
• Carmen Amador,

  Roles Writing – review & editing

  Affiliation MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, United Kingdom

  http://orcid.org/0000-0002-8464-705X

  ⨯
• Pau Navarro,

  Roles Writing – review & editing

  Affiliation MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, United Kingdom

  ⨯
• Igor Rudan,

  Roles Funding acquisition, Resources, Writing – review & editing

  Affiliation Centre for Global Health Research, Usher Institute, University of Edinburgh, Teviot Place, Edinburgh, Scotland, United Kingdom

  ⨯
• Alan F. Wright,

  Roles Funding acquisition, Resources, Writing – review & editing

  Affiliation MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, United Kingdom

  ⨯
• Harry Campbell,

  Roles Funding acquisition, Resources, Writing – review & editing

  Affiliation Centre for Global Health Research, Usher Institute, University of Edinburgh, Teviot Place, Edinburgh, Scotland, United Kingdom

  http://orcid.org/0000-0002-6169-6262

  ⨯
• Veronique Vitart,

  Roles Conceptualization, Data curation, Funding acquisition, Resources, Writing – review & editing

  Affiliation MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, United Kingdom

  http://orcid.org/0000-0002-4991-3797

  ⨯
• Caroline Hayward,

  Roles Conceptualization, Data curation, Funding acquisition, Resources, Writing – review & editing

  Affiliation MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, United Kingdom

  http://orcid.org/0000-0002-9405-9550

  ⨯
• James F. Wilson,

  Roles Conceptualization, Data curation, Funding acquisition, Resources, Writing – review & editing

  Affiliations MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, United Kingdom, Centre for Global Health Research, Usher Institute, University of Edinburgh, Teviot Place, Edinburgh, Scotland, United Kingdom

  http://orcid.org/0000-0001-5751-9178

  ⨯
• Albert Tenesa,

  Roles Data curation, Formal analysis, Software, Writing – review & editing

  Affiliations MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, United Kingdom, The Roslin Institute, University of Edinburgh, Easter Bush, Edinburgh, Scotland, United Kingdom

  http://orcid.org/0000-0003-4884-4475

  ⨯
• Chris P. Ponting,

  Roles Conceptualization, Methodology, Visualization, Writing – original draft, Writing – review & editing

  Affiliation MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, United Kingdom

  http://orcid.org/0000-0003-0202-7816

  ⨯
• J. Kenneth Baillie,

  Roles Conceptualization, Formal analysis, Methodology, Visualization, Writing – original draft, Writing – review & editing

  Affiliation The Roslin Institute, University of Edinburgh, Easter Bush, Edinburgh, Scotland, United Kingdom

  http://orcid.org/0000-0001-5258-793X

  ⨯
•  [ ... ],
• Chris Haley

  Roles Conceptualization, Data curation, Funding acquisition, Methodology, Resources, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: a.bretherick@ed.ac.uk (ADB); chris.haley@igmm.ed.ac.uk (CH)

  Affiliations MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, United Kingdom, The Roslin Institute, University of Edinburgh, Easter Bush, Edinburgh, Scotland, United Kingdom

  http://orcid.org/0000-0002-9811-0210

  ⨯
• [ view all ]
• [ view less ]