Pathological mechanism and antisense oligonucleotide-mediated rescue of a non-coding variant suppressing factor 9 RNA biogenesis leading to hemophilia B

• Simon Krooss,

  Roles Investigation, Writing – original draft

  Affiliations Institute of Virology, Hannover Medical School, Hannover, Germany, Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School and Twincore Centre for Experimental and Clinical Infection Research, Hannover, Germany

  http://orcid.org/0000-0001-6372-395X

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• Sonja Werwitzke,

  Roles Formal analysis, Resources, Writing – review & editing

  Affiliation Clinic of Hematology, Oncology and Hemostaseology, Hannover Medical School, Hannover, Germany

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• Johannes Kopp,

  Roles Methodology

  Affiliation Institute of Virology, Hannover Medical School, Hannover, Germany

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• Alice Rovai,

  Roles Methodology

  Affiliation Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School and Twincore Centre for Experimental and Clinical Infection Research, Hannover, Germany

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• Dirk Varnholt,

  Roles Formal analysis, Methodology, Writing – review & editing

  Affiliation Clinic of Hematology, Oncology and Hemostaseology, Hannover Medical School, Hannover, Germany

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• Amelie S. Wachs,

  Roles Formal analysis, Resources, Writing – review & editing

  Affiliation Institute of Virology, Hannover Medical School, Hannover, Germany

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• Aurelie Goyenvalle,

  Roles Resources, Writing – review & editing

  Affiliation Université de Versailles St-Quentin en Yvelines, INSERM U1179, France

  http://orcid.org/0000-0003-3938-1165

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• Annemieke Aarstma-Rus,

  Roles Resources, Writing – review & editing

  Affiliation Leiden University Medical Center, Leiden, Netherlands

  http://orcid.org/0000-0003-1565-654X

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• Michael Ott,

  Roles Resources, Writing – review & editing

  Affiliation Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School and Twincore Centre for Experimental and Clinical Infection Research, Hannover, Germany

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• Andreas Tiede,

  Roles Conceptualization, Methodology, Resources, Writing – review & editing

  Affiliation Clinic of Hematology, Oncology and Hemostaseology, Hannover Medical School, Hannover, Germany

  http://orcid.org/0000-0002-3600-8536

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• Jörg Langemeier ,

  Roles Conceptualization, Investigation, Methodology, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: joerglangemeier@web.de (JL); bohne.jens@mh-hannover.de (JB)

  Affiliations Institute of Virology, Hannover Medical School, Hannover, Germany, Pediatric Intensive Care Unit, Children’s Hospital Bielefeld, Germany

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• Jens Bohne

  Roles Conceptualization, Funding acquisition, Investigation, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: joerglangemeier@web.de (JL); bohne.jens@mh-hannover.de (JB)

  Affiliation Institute of Virology, Hannover Medical School, Hannover, Germany

  http://orcid.org/0000-0002-2800-9934

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