A missense variant in Mitochondrial Amidoxime Reducing Component 1 gene and protection against liver disease

• Connor A. Emdin,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America, Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America

  http://orcid.org/0000-0003-2337-1229

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• Mary E. Haas,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliations Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America, Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America

  http://orcid.org/0000-0002-2816-9268

  ⨯
• Amit V. Khera,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliations Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America, Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America

  http://orcid.org/0000-0001-6535-5839

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• Krishna Aragam,

  Roles Formal analysis, Investigation, Writing – review & editing

  Affiliations Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America, Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America

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• Mark Chaffin,

  Roles Investigation, Writing – review & editing

  Affiliation Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America

  http://orcid.org/0000-0002-1234-5562

  ⨯
• Derek Klarin,

  Roles Data curation, Formal analysis, Investigation, Validation, Writing – review & editing

  Affiliation Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America

  http://orcid.org/0000-0002-4636-5780

  ⨯
• George Hindy,

  Roles Data curation, Formal analysis, Validation, Writing – review & editing

  Affiliation Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America

  ⨯
• Lan Jiang,

  Roles Data curation, Formal analysis, Investigation, Validation, Writing – review & editing

  Affiliations Departments of Biomedical Informatics, Vanderbilt University, Vanderbilt, Tennessee, United States of America, Departments of Medicine, Vanderbilt University, Vanderbilt, Tennessee, United States of America

  http://orcid.org/0000-0002-2583-3661

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• Wei-Qi Wei,

  Roles Data curation, Investigation, Writing – review & editing

  Affiliation Departments of Biomedical Informatics, Vanderbilt University, Vanderbilt, Tennessee, United States of America

  http://orcid.org/0000-0003-4985-056X

  ⨯
• Qiping Feng,

  Roles Data curation, Formal analysis, Investigation, Validation, Writing – review & editing

  Affiliation Departments of Medicine, Vanderbilt University, Vanderbilt, Tennessee, United States of America

  http://orcid.org/0000-0002-6213-793X

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• Juha Karjalainen,

  Roles Data curation, Formal analysis, Investigation, Validation, Writing – review & editing

  Affiliations Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America, Institute for Molecular Medicine Finland (FIMM), University of Helsinki, FI, Helsinki, Finland

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• Aki Havulinna,

  Roles Data curation, Formal analysis, Investigation, Validation, Writing – review & editing

  Affiliation Institute for Molecular Medicine Finland (FIMM), University of Helsinki, FI, Helsinki, Finland

  http://orcid.org/0000-0002-4787-8959

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• Tuomo Kiiskinen,

  Roles Validation, Writing – review & editing

  Affiliation Institute for Molecular Medicine Finland (FIMM), University of Helsinki, FI, Helsinki, Finland

  http://orcid.org/0000-0002-6306-8227

  ⨯
• Alexander Bick,

  Roles Data curation, Formal analysis, Investigation, Writing – review & editing

  Affiliation Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America

  http://orcid.org/0000-0001-5824-9595

  ⨯
• Diego Ardissino,

  Roles Data curation, Formal analysis, Funding acquisition, Project administration, Writing – review & editing

  Affiliations Division of Cardiology, Azienda Ospedaliero–Universitaria di Parma, Parma, Italy, Associazione per lo Studio Della Trombosi in Cardiologia, Pavia, Italy

  http://orcid.org/0000-0003-0410-3528

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• James G. Wilson,

  Roles Data curation, Funding acquisition, Project administration, Writing – review & editing

  Affiliation Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi, United States of America

  ⨯
• Heribert Schunkert,

  Roles Data curation, Funding acquisition, Project administration, Writing – review & editing

  Affiliation Deutsches Herzzentrum München, Technische Universität München, Deutsches Zentrum für Herz-Kreislauf-Forschung, München, Germany

  http://orcid.org/0000-0001-6428-3001

  ⨯
• Ruth McPherson,

  Roles Data curation, Formal analysis, Funding acquisition, Project administration, Writing – review & editing

  Affiliation University of Ottawa Heart Institute, Ottawa, Ontario, Canada

  http://orcid.org/0000-0002-9087-6107

  ⨯
• Hugh Watkins,

  Roles Data curation, Funding acquisition, Project administration, Writing – review & editing

  Affiliations Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

  ⨯
• Roberto Elosua,

  Roles Data curation, Funding acquisition

  Affiliations Cardiovascular Epidemiology and Genetics, Hospital del Mar Research Institute, Barcelona, Spain, CIBER Enfermedades Cardiovasculares (CIBERCV), Barcelona, Spain, Facultat de Medicina, Universitat de Vic-Central de Cataluña, Vic, Spain

  ⨯
• Matthew J. Bown,

  Roles Data curation, Funding acquisition, Investigation, Writing – review & editing

  Affiliation Department of Cardiovascular Sciences, University of Leicester, and NIHR Leicester Biomedical Research Centre, Leicester, United Kingdom

  ⨯
• Nilesh J. Samani,

  Roles Data curation, Formal analysis, Investigation, Writing – review & editing

  Affiliation Department of Cardiovascular Sciences, University of Leicester, and NIHR Leicester Biomedical Research Centre, Leicester, United Kingdom

  ⨯
• Usman Baber,

  Roles Data curation, Formal analysis, Writing – review & editing

  Affiliation The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America

  ⨯
• Jeanette Erdmann,

  Roles Data curation, Formal analysis, Investigation, Writing – review & editing

  Affiliations Institute for Cardiogenetics, University of Lübeck, Lübeck, Germany, DZHK (German Research Centre for Cardiovascular Research), partner site Hamburg/Lübeck/Kiel, Lübeck, Germany

  http://orcid.org/0000-0002-4486-6231

  ⨯
• Namrata Gupta,

  Roles Data curation, Formal analysis, Funding acquisition, Writing – review & editing

  Affiliation Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America

  ⨯
• John Danesh,

  Roles Data curation, Formal analysis, Investigation, Writing – review & editing

  Affiliations Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom, Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom, National Institute of Health Research Blood and Transplant; Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, United Kingdom

  ⨯
• Danish Saleheen,

  Roles Data curation, Formal analysis, Writing – review & editing

  Affiliations Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Center for Non-Communicable Diseases, Karachi, Pakistan

  ⨯
• Kyong-Mi Chang,

  Roles Data curation, Formal analysis, Investigation, Writing – review & editing

  Affiliation Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

  http://orcid.org/0000-0001-6811-9364

  ⨯
• Marijana Vujkovic,

  Roles Data curation, Formal analysis, Investigation, Writing – review & editing

  Affiliation Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

  http://orcid.org/0000-0003-4924-5714

  ⨯
• Ben Voight,

  Roles Data curation, Formal analysis, Writing – review & editing

  Affiliation Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

  http://orcid.org/0000-0002-6205-9994

  ⨯
• Scott Damrauer,

  Roles Data curation, Funding acquisition, Investigation, Project administration, Writing – review & editing

  Affiliation Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

  http://orcid.org/0000-0001-8009-1632

  ⨯
• Julie Lynch,

  Roles Data curation, Investigation, Writing – review & editing

  Affiliation Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

  http://orcid.org/0000-0003-0108-2127

  ⨯
• David Kaplan,

  Roles Data curation, Formal analysis, Writing – review & editing

  Affiliation Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

  http://orcid.org/0000-0002-3839-336X

  ⨯
• Marina Serper,

  Roles Data curation, Formal analysis, Project administration, Writing – review & editing

  Affiliation Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

  http://orcid.org/0000-0003-4899-2160

  ⨯
• Philip Tsao,

  Roles Data curation, Formal analysis, Writing – review & editing

  Affiliation Veterans Affairs Palo Alto Health Care System, Palo Alto, California, United States of America

  http://orcid.org/0000-0001-7274-9318

  ⨯
• Million Veteran Program,
• Josep Mercader,

  Roles Data curation, Formal analysis, Investigation, Writing – review & editing

  Affiliations Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America, Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America

  http://orcid.org/0000-0001-8494-3660

  ⨯
• Craig Hanis,

  Roles Data curation, Formal analysis, Writing – review & editing

  Affiliation Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America

  http://orcid.org/0000-0002-4880-5348

  ⨯
• Mark Daly,

  Roles Data curation, Formal analysis, Investigation, Writing – review & editing

  Affiliation Institute for Molecular Medicine Finland (FIMM), University of Helsinki, FI, Helsinki, Finland

  ⨯
• Joshua Denny,

  Roles Data curation, Formal analysis, Investigation, Writing – review & editing

  Affiliations Departments of Biomedical Informatics, Vanderbilt University, Vanderbilt, Tennessee, United States of America, Departments of Medicine, Vanderbilt University, Vanderbilt, Tennessee, United States of America

  http://orcid.org/0000-0002-3049-7332

  ⨯
• Stacey Gabriel,

  Roles Data curation, Formal analysis, Investigation, Project administration, Writing – review & editing

  Affiliation Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America

  ⨯
•  [ ... ],
• Sekar Kathiresan

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: skathiresan@vervetx.com

  Affiliations Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America, Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Verve Therapeutics, Boston, Massachusetts, United States of America

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