Chromatin modifiers and recombination factors promote a telomere fold-back structure, that is lost during replicative senescence

Tina Wagner; Lara Pérez-Martínez; René Schellhaas; Marta Barrientos-Moreno; Merve Öztürk; Félix Prado; Falk Butter; Brian Luke

doi:10.1371/journal.pgen.1008603

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Open Access

Peer-reviewed

Research Article

Chromatin modifiers and recombination factors promote a telomere fold-back structure, that is lost during replicative senescence

Tina Wagner,

Roles Conceptualization, Investigation, Methodology, Writing – original draft, Writing – review & editing

Affiliations Institute of Developmental Biology and Neurobiology (IDN), Johannes Gutenberg-Universität, Mainz, Germany, Institute of Molecular Biology (IMB) gGmbH, Mainz, Germany
⨯
Lara Pérez-Martínez,

Roles Investigation, Methodology

Affiliation Institute of Molecular Biology (IMB) gGmbH, Mainz, Germany
⨯
René Schellhaas,

Roles Investigation, Methodology

Affiliation Institute of Molecular Biology (IMB) gGmbH, Mainz, Germany
⨯
Marta Barrientos-Moreno,

Roles Investigation

Affiliation Department of Genome Biology, Andalusian Molecular Biology and Regenerative Medicine Center (CABIMER), CSIC-University of Seville-University Pablo de Olavide, Seville, Spain

https://orcid.org/0000-0002-2709-8437

⨯
Merve Öztürk,

Roles Data curation, Formal analysis

Affiliation Institute of Molecular Biology (IMB) gGmbH, Mainz, Germany

https://orcid.org/0000-0003-2898-2176

⨯
Félix Prado,

Roles Funding acquisition, Supervision, Writing – review & editing

Affiliation Department of Genome Biology, Andalusian Molecular Biology and Regenerative Medicine Center (CABIMER), CSIC-University of Seville-University Pablo de Olavide, Seville, Spain

https://orcid.org/0000-0001-9805-782X

⨯
Falk Butter,

Roles Data curation, Funding acquisition, Methodology, Supervision, Writing – review & editing

Affiliation Institute of Molecular Biology (IMB) gGmbH, Mainz, Germany

https://orcid.org/0000-0002-7197-7279

⨯
Brian Luke

Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – original draft, Writing – review & editing

* E-mail: b.luke@imb-mainz.de

Affiliations Institute of Developmental Biology and Neurobiology (IDN), Johannes Gutenberg-Universität, Mainz, Germany, Institute of Molecular Biology (IMB) gGmbH, Mainz, Germany

https://orcid.org/0000-0002-1648-5511

⨯

Chromatin modifiers and recombination factors promote a telomere fold-back structure, that is lost during replicative senescence

Tina Wagner,
Lara Pérez-Martínez,
René Schellhaas,
Marta Barrientos-Moreno,
Merve Öztürk,
Félix Prado,
Falk Butter,
Brian Luke

Published: December 28, 2020
https://doi.org/10.1371/journal.pgen.1008603

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Telomeres
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Chromatin
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Yeast
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Histones
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DNA damage
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Polymerase chain reaction
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Chromosome structure and function
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Saccharomyces cerevisiae
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