Autophagy gene haploinsufficiency drives chromosome instability, increases migration, and promotes early ovarian tumors

• Joe R. Delaney ,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: delaneyj@musc.edu (JRD); al.laspada@duke.edu (ARLS); dstupack@ucsd.edu (DGS)

  Affiliations UC San Diego Moores Cancer Center, La Jolla, California, United States of America, Department of Obstetrics, Gynecology, and Reproductive Sciences, UC San Diego School of Medicine, La Jolla, California, United States of America, Departments of Neurology, Neurobiology, and Cell Biology, and the Duke Center for Neurodegeneration & Neurotherapeutics, Duke University School of Medicine, Durham, North Carolina, United States of America, Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina, United States of America, Department of Pediatrics and Division of Biological Sciences, UC San Diego School of Medicine, La Jolla, California, United States of America

  http://orcid.org/0000-0002-8978-5961

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• Chandni B. Patel,

  Roles Formal analysis, Investigation, Validation, Visualization

  Affiliations UC San Diego Moores Cancer Center, La Jolla, California, United States of America, Department of Obstetrics, Gynecology, and Reproductive Sciences, UC San Diego School of Medicine, La Jolla, California, United States of America

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• Jaidev Bapat,

  Roles Formal analysis, Investigation, Validation, Visualization

  Affiliations UC San Diego Moores Cancer Center, La Jolla, California, United States of America, Department of Obstetrics, Gynecology, and Reproductive Sciences, UC San Diego School of Medicine, La Jolla, California, United States of America, Department of Pediatrics and Division of Biological Sciences, UC San Diego School of Medicine, La Jolla, California, United States of America

  http://orcid.org/0000-0002-8964-1415

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• Christian M. Jones,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliation Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina, United States of America

  http://orcid.org/0000-0002-0914-2967

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• Maria Ramos-Zapatero,

  Roles Formal analysis, Investigation, Validation

  Affiliations UC San Diego Moores Cancer Center, La Jolla, California, United States of America, Department of Obstetrics, Gynecology, and Reproductive Sciences, UC San Diego School of Medicine, La Jolla, California, United States of America, Department of Pediatrics and Division of Biological Sciences, UC San Diego School of Medicine, La Jolla, California, United States of America

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• Katherine K. Ortell,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliation Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina, United States of America

  http://orcid.org/0000-0003-3192-4452

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• Ralph Tanios,

  Roles Investigation, Writing – review & editing

  Affiliation Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina, United States of America

  http://orcid.org/0000-0003-1189-0777

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• Mina Haghighiabyaneh,

  Roles Investigation

  Affiliations UC San Diego Moores Cancer Center, La Jolla, California, United States of America, Department of Obstetrics, Gynecology, and Reproductive Sciences, UC San Diego School of Medicine, La Jolla, California, United States of America

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• Joshua Axelrod,

  Roles Investigation

  Affiliations UC San Diego Moores Cancer Center, La Jolla, California, United States of America, Department of Obstetrics, Gynecology, and Reproductive Sciences, UC San Diego School of Medicine, La Jolla, California, United States of America

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• John W. DeStefano,

  Roles Investigation

  Affiliation Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina, United States of America

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• Isabelle Tancioni,

  Roles Investigation, Methodology

  Affiliations UC San Diego Moores Cancer Center, La Jolla, California, United States of America, Department of Obstetrics, Gynecology, and Reproductive Sciences, UC San Diego School of Medicine, La Jolla, California, United States of America

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• David D. Schlaepfer,

  Roles Conceptualization, Writing – review & editing

  Affiliations UC San Diego Moores Cancer Center, La Jolla, California, United States of America, Department of Obstetrics, Gynecology, and Reproductive Sciences, UC San Diego School of Medicine, La Jolla, California, United States of America

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• Olivier Harismendy,

  Roles Resources, Writing – review & editing

  Affiliations UC San Diego Moores Cancer Center, La Jolla, California, United States of America, Division of Biomedical Informatics, Department of Medicine, UC San Diego School of Medicine, La Jolla, California, United States of America

  http://orcid.org/0000-0002-8098-9888

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• Albert R. La Spada ,

  Roles Writing – review & editing

  * E-mail: delaneyj@musc.edu (JRD); al.laspada@duke.edu (ARLS); dstupack@ucsd.edu (DGS)

  Affiliations Departments of Neurology, Neurobiology, and Cell Biology, and the Duke Center for Neurodegeneration & Neurotherapeutics, Duke University School of Medicine, Durham, North Carolina, United States of America, Department of Pediatrics and Division of Biological Sciences, UC San Diego School of Medicine, La Jolla, California, United States of America

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• Dwayne G. Stupack

  Roles Conceptualization, Methodology, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: delaneyj@musc.edu (JRD); al.laspada@duke.edu (ARLS); dstupack@ucsd.edu (DGS)

  Affiliations UC San Diego Moores Cancer Center, La Jolla, California, United States of America, Department of Obstetrics, Gynecology, and Reproductive Sciences, UC San Diego School of Medicine, La Jolla, California, United States of America

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