Defects in the GINS complex increase the instability of repetitive sequences via a recombination-dependent mechanism

Malgorzata Jedrychowska; Milena Denkiewicz-Kruk; Malgorzata Alabrudzinska; Adrianna Skoneczna; Piotr Jonczyk; Michal Dmowski; Iwona J. Fijalkowska

doi:10.1371/journal.pgen.1008494

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Open Access

Peer-reviewed

Research Article

Defects in the GINS complex increase the instability of repetitive sequences via a recombination-dependent mechanism

Malgorzata Jedrychowska,

Roles Data curation, Investigation

Affiliation Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland
⨯
Milena Denkiewicz-Kruk,

Roles Data curation, Investigation

Affiliation Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland
⨯
Malgorzata Alabrudzinska,

Roles Conceptualization, Data curation, Investigation

Affiliation Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland
⨯
Adrianna Skoneczna,

Roles Data curation, Investigation

Affiliation Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland

http://orcid.org/0000-0003-4059-2146

⨯
Piotr Jonczyk,

Roles Investigation

Affiliation Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland
⨯
Michal Dmowski ,

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Supervision, Visualization, Writing – original draft, Writing – review & editing

* E-mail: mdmowski@ibb.waw.pl (MD); iwonaf@ibb.waw.pl (IJF)

Affiliation Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland

http://orcid.org/0000-0002-6571-6259

⨯
Iwona J. Fijalkowska

Roles Conceptualization, Formal analysis, Funding acquisition, Supervision, Writing – original draft, Writing – review & editing

* E-mail: mdmowski@ibb.waw.pl (MD); iwonaf@ibb.waw.pl (IJF)

Affiliation Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland

http://orcid.org/0000-0002-5307-4332

⨯

Defects in the GINS complex increase the instability of repetitive sequences via a recombination-dependent mechanism

Malgorzata Jedrychowska,
Milena Denkiewicz-Kruk,
Malgorzata Alabrudzinska,
Adrianna Skoneczna,
Piotr Jonczyk,
Michal Dmowski,
Iwona J. Fijalkowska

Published: December 9, 2019
https://doi.org/10.1371/journal.pgen.1008494

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DNA replication
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Yeast
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DNA repair
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Protein structure networks
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DNA recombination
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Repeated sequences
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Saccharomyces cerevisiae
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