CRISPR editing of sftb-1/SF3B1 in Caenorhabditis elegans allows the identification of synthetic interactions with cancer-related mutations and the chemical inhibition of splicing

• Xènia Serrat,

  Roles Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Modeling human diseases in C. elegans Group, Genes, Disease and Therapy Program, Institut d’Investigació Biomèdica de Bellvitge–IDIBELL, Barcelona, Spain

  http://orcid.org/0000-0001-7611-5400

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• Dmytro Kukhtar,

  Roles Investigation, Methodology

  Affiliation Modeling human diseases in C. elegans Group, Genes, Disease and Therapy Program, Institut d’Investigació Biomèdica de Bellvitge–IDIBELL, Barcelona, Spain

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• Eric Cornes,

  Roles Investigation, Methodology

  Affiliation Mechanisms of Epigenetic Inheritance, Department of Developmental and Stem Cell Biology, Institut Pasteur, UMR3738, CNRS, Paris, France

  http://orcid.org/0000-0002-2938-3733

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• Anna Esteve-Codina,

  Roles Formal analysis

  Affiliations CNAG‐CRG, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain, Universitat Pompeu Fabra (UPF), Barcelona, Spain

  http://orcid.org/0000-0003-0361-2873

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• Helena Benlloch,

  Roles Methodology

  Affiliation Modeling human diseases in C. elegans Group, Genes, Disease and Therapy Program, Institut d’Investigació Biomèdica de Bellvitge–IDIBELL, Barcelona, Spain

  http://orcid.org/0000-0002-7319-0963

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• Germano Cecere,

  Roles Methodology

  Affiliation Mechanisms of Epigenetic Inheritance, Department of Developmental and Stem Cell Biology, Institut Pasteur, UMR3738, CNRS, Paris, France

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• Julián Cerón

  Roles Conceptualization, Funding acquisition, Investigation, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: jceron@idibell.cat

  Affiliation Modeling human diseases in C. elegans Group, Genes, Disease and Therapy Program, Institut d’Investigació Biomèdica de Bellvitge–IDIBELL, Barcelona, Spain

  http://orcid.org/0000-0003-4739-2243

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